General
Preferred name
BUSPIRONE
Synonyms
BUSPIRONE HYDROCHLORIDE ()
Ansial ()
Buspirone HCl ()
Narol ()
Buspar ()
Buspirone (hydrochloride) ()
Buspirone (hydrochloride) ()
APD405 ()
MJ 9022-1 ()
NSC-751138 ()
MJ-9022-1 ()
NSC-759571 ()
APD-405 ()
Buspirona ()
Gen-buspirone ()
BCI-024 ()
Buspirone-d8 (hydrochloride) ()
Buspirone (hydrochloride) (CRM) ()
P&D ID
PD009997
CAS
36505-84-7
116753-41-4
33386-08-2
1216761-39-5
Tags
available
drug
Approved by
FDA
First approval
1986
Drug indication
Anxiety disorder
Anxiety
Sexual dysfunction
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research[1][2].
DESCRIPTION
Buspirone is an anxiolytic psychotropic drug.
(GtoPdb)
DESCRIPTION
Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research[1].
PRICE
35
DESCRIPTION
Potent group III mGlu antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT1A Serotonin receptor agonist; non-benzodiazepine anxiolytic
(LOPAC library)
DESCRIPTION
5-HT1A partial agonist
(Tocriscreen Total)
DESCRIPTION
Buspirone is an anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression.
(Enamine Bioactive Compounds)
DESCRIPTION
Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
33
Axon Medchem Screening Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
77
Molecular Weight
385.25
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
1
cLogP
2.09
TPSA
69.64
Fraction CSP3
0.71
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
MOA
serotonin receptor agonist
Agonist
5-HT1A Receptor Agonists
ADRA1B partial agonist
Target
Sigma non-opioid intracellular receptor 1
D(4) dopamine receptor
Serotonin 1a (5-HT1a) receptor
D(2) dopamine receptor
5-HT
5-HT Receptor
dopamine
DRD2, HTR1A
5-HT1A agonist
Reactive Oxygen Species (ROS)
Dopamine Receptor
Reactive Oxygen Species
Primary Target
5-HT1A Receptors
Member status
virtual
Indication
generalized anxiety disorder (GAD)
Therapeutic Class
Antianxiety Agents
Pathway
GPCR/G protein
Immunology/Inflammation
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Neuroscience
NF-¦ÊB
Source data
