General
Preferred name
BUSPIRONE
Synonyms
BUSPIRONE HYDROCHLORIDE ()
Buspirone HCl ()
Buspar ()
Narol ()
Buspirone (hydrochloride) ()
MJ 9022-1 ()
APD-405 ()
NSC-759571 ()
MJ-9022-1 ()
APD405 ()
NSC-751138 ()
Gen-buspirone ()
BCI-024 ()
Buspirone (hydrochloride) ()
P&D ID
PD009997
CAS
36505-84-7
116753-41-4
33386-08-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1986
Drug Status
investigational
approved
Drug indication
Anxiety disorder
Tranquilizer (minor)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Buspirone is an anxiolytic psychotropic drug.
(GtoPdb)
DESCRIPTION
Potent group III mGlu antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT1A Serotonin receptor agonist; non-benzodiazepine anxiolytic
(LOPAC library)
DESCRIPTION
5-HT1A partial agonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
31
Axon Medchem Screening Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
385.25
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
1
cLogP
2.09
TPSA
69.64
Fraction CSP3
0.71
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
MOA
serotonin receptor agonist
Agonist
5-HT1A Receptor Agonists
ADRA1B partial agonist
Target
Sigma non-opioid intracellular receptor 1
D(4) dopamine receptor
Serotonin 1a (5-HT1a) receptor
D(2) dopamine receptor
5-HT
dopamine
DRD2, HTR1A
5-HT1A agonist
5-HT Receptor
Reactive Oxygen Species
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Primary Target
5-HT1A Receptors
Member status
virtual
Indication
generalized anxiety disorder (GAD)
Therapeutic Class
Antianxiety Agents
Source data
