General
Preferred name
TOLMETIN
Synonyms
TOLMETIN SODIUM ()
Tolectin ()
Tolmetin sodium salt dihydrate ()
Tolmetin (sodium dihydrate) ()
tolmetin, Gilead ()
MCN2559 ()
Tolmetin sodium anhydrous ()
Tolectin DS ()
Tolectin 600 ()
Sodium tolmetin ()
Tolmetin sodium dihydrate ()
NSC-757341 ()
McN-2559-21-98 ()
MCN-2559 ()
Tolmetin (sodium salt hydrate) ()
P&D ID
PD009991
CAS
64490-92-2
26171-23-3
35711-34-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1976
Drug Status
approved
Drug indication
Rheumatoid arthritis
Anti-Inflammatory
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic activity.
Marketed formulations may contain tolmetin sodium (PubChem CID 23665411). (GtoPdb)
Compound Sets
24
Cayman Chemical Bioactives
18195
ChEMBL Approved Drugs
CHEMBL1200613
CHEMBL1020
ChEMBL Drugs
CHEMBL1200613
CHEMBL1020
Drug Repurposing Hub
DrugBank
DB00500
DrugBank Approved Drugs
DB00500
DrugCentral
2699
DrugCentral Approved Drugs
2699
DrugMAP
DMWUIJE
DrugMAP Approved Drugs
DMWUIJE
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7311
Ki Database
Tolmetin
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1020
MedChem Express Bioactive Compound Library
HY-B1489
HY-B1799
NCATS Inxight Approved Drugs
D8K2JPN18B
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tolmetin-sodium
tolmetin
TargetMol Bioactive Compound Library
T2550
The Spectrum Collection
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
257.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.19
TPSA
59.3
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Neuroscience
Target
COX-1
COX-2
PTGS1, PTGS2
COX
Immunology & Inflammation related
Indication
rheumatoid arthritis, osteoarthritis
MOA
cyclooxygenase inhibitor
Therapeutic Class
Antiinflammatory Agents
Source data