General
Preferred name
TOLMETIN
Synonyms
TOLMETIN SODIUM ()
Tolectin ()
Tolmetin sodium salt dihydrate ()
tolmetin, Gilead ()
Tolmetin (sodium dihydrate) ()
MCN2559 ()
Tolmetin (sodium salt hydrate) ()
Sodium tolmetin ()
Tolmetin sodium dihydrate ()
Tolectin 600 ()
Tolmetin sodium anhydrous ()
McN-2559-21-98 ()
Tolectin DS ()
NSC-757341 ()
Tolmetine ()
MCN-2559 ()
Tolmetina ()
P&D ID
PD009991
CAS
64490-92-2
26171-23-3
35711-34-3
Tags
available
drug
Approved by
FDA
First approval
1976
Drug indication
Arthralgia
Rheumatoid arthritis
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tolmetin sodium dihydrate is an orally active and potent COX inhibitor with IC50s of 0.35 ¦ÌM and 0.82 ¦ÌM human COX-1 and COX-2, respectively. Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory drug (NSAID)[1][2].
DESCRIPTION Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic activity.
Marketed formulations may contain tolmetin sodium (PubChem CID 23665411). (GtoPdb)
DESCRIPTION Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 ¦ÌM and 0.82 ¦ÌM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID)[1][2].
PRICE 29
DESCRIPTION Tolmetin is a potent COX inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) and also exhibits analgesic and antipyretic activity. (Enamine Bioactive Compounds)
DESCRIPTION Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds. (TargetMol Bioactive Compound Library)
Compound Sets
25
Cayman Chemical Bioactives
18195
ChEMBL Approved Drugs
CHEMBL1200613
CHEMBL1020
ChEMBL Drugs
CHEMBL1200613
CHEMBL1020
Drug Repurposing Hub
DrugBank
DB00500
DrugBank Approved Drugs
DB00500
DrugCentral
2699
DrugCentral Approved Drugs
2699
DrugMAP
DMWUIJE
DrugMAP Approved Drugs
DMWUIJE
DrugMatrix
Enamine Bioactive Compounds
EBC-03893
Enamine BioReference Compounds
Guide to Pharmacology
7311
Ki Database
Tolmetin
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1020
MedChem Express Bioactive Compound Library
HY-B1489
HY-B1799
NCATS Inxight Approved Drugs
D8K2JPN18B
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tolmetin-sodium
tolmetin
TargetMol Bioactive Compound Library
T2550
The Spectrum Collection
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
257.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.19
TPSA
59.3
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
COX-1
COX-2
PTGS1, PTGS2
Immunology & Inflammation related
Indication
rheumatoid arthritis, osteoarthritis
MOA
cyclooxygenase inhibitor
Therapeutic Class
Antiinflammatory Agents
Pathway
Immunology/Inflammation
Neuroscience
Source data