General
Preferred name
trandolapril
Synonyms
RU44570 ()
Trandolapril ()
RU 44570 ()
Odrik ()
RU-44570 ()
Gopten ()
NSC-758939 ()
INDOLAPRIL ()
Mavik ()
Trandolapril component of tarka ()
P&D ID
PD009982
CAS
87679-37-6
Tags
available
prodrug
drug
Approved by
FDA
First approval
1996
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Trandolapril (RU44570) is a nonsulfhydryl proagent that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI)[1].
PRICE
57
DESCRIPTION
Metabolized to its biologically active diacid (drug) trandolaprilat in the liver.
(GtoPdb)
DESCRIPTION
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
430.25
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
1
cLogP
2.77
TPSA
95.94
Fraction CSP3
0.62
Chiral centers
5.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin-converting Enzyme (ACE)
ACE
ACE,RAAS
Indication
hypertension, myocardial infarction
MOA
angiotensin converting enzyme inhibitor
Therapeutic Class
Antihypertensive Agents
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
