General
Preferred name
GUANIDINE
Synonyms
GUANIDINE CARBONATE ()
GUANIDINE HYDROCHLORIDE ()
Aminoformamidine Hydrochloride ()
Guanidinium chloride ()
Guanidine HCl ()
Aminoformamidine HCl ()
Guanidine (hydrochloride) ()
Guanidine thiocyanate ()
Guanidinium (chloride) ()
Aminoformamidine (hydrochloride) ()
GTC ()
P&D ID
PD009973
CAS
593-85-1
50-01-1
124-46-9
106946-18-3
113-00-8
593-84-0
109028-07-1
Tags
available
drug
Approved by
FDA
First approval
1939
Drug Status
approved
Drug indication
Muscle fatigue
Myasthenic syndrome
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Guanidine is the functional group on the side chain of arginine (). It is a normal product of protein metabolism and is excreted by the kidney. (GtoPdb)
Compound Sets
20
ChEMBL Approved Drugs
CHEMBL1200728
CHEMBL821
ChEMBL Drugs
CHEMBL1200728
CHEMBL821
Concise Guide to Pharmacology 2017/18
4783
Concise Guide to Pharmacology 2019/20
4783
Concise Guide to Pharmacology 2021/22
4783
Concise Guide to Pharmacology 2023/24
4783
Drug Repurposing Hub
DrugBank
DB00536
DrugBank Approved Drugs
DB00536
DrugCentral
1344
DrugCentral Approved Drugs
1344
DrugMAP
DM0P63W
DM4GO8H
DrugMAP Approved Drugs
DM0P63W
Guide to Pharmacology
4783
JUMP-Target 1 Compound Set
3520
MedChem Express Bioactive Compound Library
HY-B0178A
HY-D0841
ReFrame library
Selleckchem Bioactive Compound Library
guanidine-aminoformamidine-hcl
TargetMol Bioactive Compound Library
T0415
The Spectrum Collection
External IDs
105
Properties
(calculated by RDKit )
Molecular Weight
59.05
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
3
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.16
TPSA
75.89
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
DNA Damage/DNA Repair
Immunology/Inflammation
Metabolic Enzyme/Protease
Target
Arginase
Lysozyme
Ribonuclease pancreatic
Argininosuccinate synthase
ALDH2, DLG4, GAMT, RNASE1
RNASE1
Endogenous Metabolite
Indication
Lambert-Eaton myasthenic syndrome (LEMS)
MOA
HSP inhibitor
Therapeutic Class
Neurology Agents
Source data