General
Preferred name
toremifene
Synonyms
TOREMIFENE CITRATE ()
NK 622 ()
FC 1157a ()
NSC 613680 ()
Z-Toremifene ()
GTx 006 ()
Toremifene (Citrate) ()
Z-Toremifene (citrate) ()
FC-1157a ()
NK 622 (free base) ()
FC-1157a (free base) ()
Toremifene Citrate (NK 622) ()
NSC 613680,NK 622 Citrate ()
NSC-613680 ()
Fareston ()
J33.157K ()
Farestone ()
Acapodene ()
Chlortamoxifen ()
Toremiphene ()
GTX-006 ()
Toremifene-d6 ()
P&D ID
PD009971
CAS
89778-26-7
275360-73-1
89778-27-8
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1997
Drug Status
investigational
approved
Drug indication
Coronavirus Disease 2019 (COVID-19)
Antineoplastic
Anti-Estrogen
Breast cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Toremifene is an orally active, selective estrogen receptor modulator (SERM). (GtoPdb)
Cell lines
2
Organisms
6
Compound Sets
27
Cayman Chemical Bioactives
20854
30728
ChEMBL Approved Drugs
CHEMBL1200675
CHEMBL1655
ChEMBL Drugs
CHEMBL1200675
CHEMBL1655
Concise Guide to Pharmacology 2017/18
4325
Concise Guide to Pharmacology 2019/20
4325
Concise Guide to Pharmacology 2021/22
4325
Concise Guide to Pharmacology 2023/24
4325
Drug Repurposing Hub
DrugBank
DB00539
DrugBank Approved Drugs
DB00539
DrugCentral
2709
DrugCentral Approved Drugs
2709
DrugMAP
DMKD6GA
DMQYUWG
DrugMAP Approved Drugs
DMQYUWG
Guide to Pharmacology
4325
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1655
Mcule NIBR MoA Box Subset
MCULE-6965711017
MedChem Express Bioactive Compound Library
HY-B0005
HY-B0005A
NCATS Inxight Approved Drugs
7NFE54O27T
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Toremifene-Citrate(Fareston)
TargetMol Bioactive Compound Library
T1464
T0139
The Spectrum Collection
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
405.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
3
cLogP
6.22
TPSA
12.47
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Apoptosis
Vitamin D Related/Nuclear Receptor
Target
ER
ESR1
Estrogen Receptor/ERR
Estrogen/progestogen Receptor
Member status
virtual
MOA
Selective Estrogen Receptor Modulators (SERM)
estrogen receptor antagonist, selective estrogen receptor modulator (SERM)
Indication
breast cancer
Therapeutic Class
Anticancer Agents
Antiviral Agents
Source data