General
Preferred name
NORTRIPTYLINE
Synonyms
NORTRIPTYLINE HYDROCHLORIDE ()
Desmethylamitriptyline hydrochloride ()
Desitriptyline HCl ()
ELF-101 hydrochloride ()
EN-7048 hydrochloride ()
NORTRYPTYLINE ()
Nortriptyline (hydrochloride) ()
Desmethylamitriptyline (hydrochloride) ()
Desitriptilina (hydrochloride) ()
Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride ()
Pamelor ()
Aventyl ()
38489 ()
Psychostyl ()
Nortriptyline hcl ()
Aventyl hydrochloride ()
NSC-169453 ()
Nortrilen ()
Motipress ()
NCI-169453 ()
Allegron ()
Noramitriptyline ()
Sesaval ()
Desitriptilina ()
NSC-757234 ()
Motival ()
Lumbeck ()
Nortriptyline (hydrochloride) ()
Nortriptyline (hydrochloride) ()
Nortriptyline (hydrochloride) (CRM) ()
P&D ID
PD009970
CAS
894-71-3
37025-22-2
72-69-5
203784-52-5
Tags
natural product
drug
available
Approved by
FDA
First approval
1964
Drug Status
approved
Drug indication
Depression
Antidepressant
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nortriptyline is a second-generation tricyclic antidepressant (TCA). (GtoPdb)
DESCRIPTION Tricyclic antidepressant (LOPAC library)
Cell lines
0
Organisms
5
Compound Sets
27
Cayman Chemical Bioactives
15904
19041
19042
ChEMBL Approved Drugs
CHEMBL1201156
CHEMBL445
ChEMBL Drugs
CHEMBL1201156
CHEMBL445
Drug Repurposing Hub
DrugBank
DB00540
DrugBank Approved Drugs
DB00540
DrugCentral
1971
DrugCentral Approved Drugs
1971
DrugMAP
DM4KDYJ
DrugMAP Approved Drugs
DM4KDYJ
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
2404
Ki Database
NORTRYPTYLINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201156
CHEMBL445
MedChem Express Bioactive Compound Library
HY-B1417
NCATS Inxight Approved Drugs
BL03SY4LXB
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nortriptyline-hydrochloride
TargetMol Bioactive Compound Library
T1327
The Spectrum Collection
ZINC Tool Compounds
ZINC000001530741
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
263.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.83
TPSA
12.03
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
7.0
QED
0.83
Structural alerts
1
styrene_A(13)
[#6]-2-[#6]-c:1:c(:c:c:c:c:1)-[#6](-c:3:c:c:c:c:c-2:3)=[#6]-[#6]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Target
5-HT
Sert (Sodium-dependent)
mAChR
Adrenergic Receptor
dopamine
H1 receptor
Noradrenaline transporter (Sodium-dependent)
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR1A, HTR2A, HTR2C, HTR6, KCNJ10, PGRMC1, SIGMAR1, SLC6A2, SLC6A4
Drug Metabolite
Member status
member
MOA
K(ir) 4.1 Blockers
tricyclic antidepressant
Indication
depression
Therapeutic Class
Antidepressants
Source data