General
Preferred name
NORTRIPTYLINE
Synonyms
NORTRIPTYLINE HYDROCHLORIDE ()
Desitriptyline HCl ()
EN-7048 hydrochloride ()
Desmethylamitriptyline hydrochloride ()
ELF-101 hydrochloride ()
NORTRYPTYLINE ()
Nortriptyline (hydrochloride) ()
Desmethylamitriptyline ()
Desitriptilina ()
Desmethylamitriptyline (hydrochloride) ()
Desitriptilina (hydrochloride) ()
Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride ()
Nortriptyline (hydrochloride) ()
Nortriptyline hcl ()
Pamelor ()
Aventyl hydrochloride ()
Aventyl ()
NSC-169453 ()
38489 ()
Psychostyl ()
Nortriptilina ()
Lumbeck ()
NSC-757234 ()
Motipress ()
Noramitriptyline ()
NCI-169453 ()
Motival ()
Nortrilen ()
Sesaval ()
Allegron ()
Nortriptyline (hydrochloride) ()
Nortriptyline (hydrochloride) (CRM) ()
P&D ID
PD009970
CAS
894-71-3
37025-22-2
72-69-5
203784-52-5
Tags
available
drug
Approved by
FDA
First approval
1964
Drug indication
psoriasis
Depression
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
PRICE 29
DESCRIPTION Nortriptyline is a second-generation tricyclic antidepressant (TCA). (GtoPdb)
DESCRIPTION Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N
PRICE 63
DESCRIPTION Tricyclic antidepressant (LOPAC library)
DESCRIPTION Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant. It is indicated for the relief of the symptoms of major depressive disorder. (Enamine Bioactive Compounds)
DESCRIPTION Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. (TargetMol Bioactive Compound Library)
DESCRIPTION Nortriptyline is an antidepressant compound that enhances corticosteroid sensitivity of blood T-cells in patients with chronic obstructive pulmonary disease (COPD) and may be used for smoking cessation. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
5
Compound Sets
28
Cayman Chemical Bioactives
15904
19041
19042
ChEMBL Approved Drugs
CHEMBL1201156
CHEMBL445
ChEMBL Drugs
CHEMBL1201156
CHEMBL445
Drug Repurposing Hub
DrugBank
DB00540
DrugBank Approved Drugs
DB00540
DrugCentral
1971
DrugCentral Approved Drugs
1971
DrugMAP
DM4KDYJ
DrugMAP Approved Drugs
DM4KDYJ
DrugMatrix
Enamine Bioactive Compounds
EBC-12661
Enamine BioReference Compounds
Guide to Pharmacology
2404
Ki Database
NORTRYPTYLINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201156
CHEMBL445
MedChem Express Bioactive Compound Library
HY-B1417
HY-118620
NCATS Inxight Approved Drugs
BL03SY4LXB
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nortriptyline-hydrochloride
TargetMol Bioactive Compound Library
T1327
T73844
The Spectrum Collection
ZINC Tool Compounds
ZINC000001530741
External IDs
70
Properties
(calculated by RDKit )
Molecular Weight
263.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.83
TPSA
12.03
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
7.0
QED
0.83
Structural alerts
1
styrene_A(13)
[#6]-2-[#6]-c:1:c(:c:c:c:c:1)-[#6](-c:3:c:c:c:c:c-2:3)=[#6]-[#6]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Autophagy
Drug Metabolite
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR1A, HTR2A, HTR2C, HTR6, KCNJ10, PGRMC1, SIGMAR1, SLC6A2, SLC6A4
5-HT
Adrenergic Receptor
dopamine
H1 receptor
mAChR
Noradrenaline transporter (Sodium-dependent)
Sert (Sodium-dependent)
Selectivity
Uptake
Pathway
GPCR/G protein
Immunology/Inflammation
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Member status
member
MOA
K(ir) 4.1 Blockers
tricyclic antidepressant
Indication
depression
Therapeutic Class
Antidepressants
Source data