General
Preferred name
vincristine
Synonyms
Leurocristine ()
VINCRISTINE SULFATE ()
22-Oxovincaleukoblastine ()
Oncovine ()
Vincrystine ()
Vinkristin ()
22-Oxovincaleukoblastine sulfate ()
Leurocristine sulfate ()
Vincristine (free base) ()
Vincristine sulfateVincristineOnkovinLeurocristine sulfateOncovinVCR sulfateAlkaloid extracted from Vinca rosea LinnVincasarVincrexKyocristine ()
Vincristini sulfas ()
Vincristine sulphate ()
Vincasar Pfs ()
Vincristine sulfate liposome ()
Vincrisul ()
Vincrex ()
Novopharm ()
37231 ()
Marqibo Kit ()
Vincristine Sulfate Pfs ()
Kyocristine ()
Marqibo ()
LILLY-37231 ()
Oncovin ()
NSC-67574 ()
Leucristine ()
Tecnocris ()
Vincaleukoblastine, 22-oxo- ()
Oncotcs ()
Vincristin ()
Vincristina ()
Vincristine-d3 ()
P&D ID
PD009969
CAS
28379-27-3
57-22-7
2068-78-2
1246817-09-3
Tags
available
drug
natural product
Drug indication
Acute lymphoblastic leukaemia
B-cell acute lymphoblastic leukemia
acute lymphoblastic leukemia
Drug Status
approved
Max Phase
4.0
First approval
1963
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A pan tubulin inhibitor, isolated from Catharanthus roseus (the Madagascar periwinkle, formerly Vinca rosea). Marketed formulations contain vincristine sulfate (PubChem CID 249332). (GtoPdb)
DESCRIPTION Disrupts microtubules (Tocriscreen Total)
DESCRIPTION p53 inhibitor. Also aryl hydrocarbon receptor agonist (Tocris Bioactive Compound Library)
DESCRIPTION Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children. (TargetMol Bioactive Compound Library)
DESCRIPTION The attenuating effect of VC in Vincristine-induced nociceptive painful sensation may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action. (BOC Sciences Bioactive Compounds)
Cell lines
88
Organisms
2
Compound Sets
20
AdooQ Bioactive Compound Library
A10973
BOC Sciences Bioactive Compounds
vincristine-cas-57-22-7-item-464460
Cayman Chemical Bioactives
34512
ChEMBL Approved Drugs
CHEMBL501867
CHEMBL90555
ChEMBL Drugs
CHEMBL501867
CHEMBL90555
Concise Guide to Pharmacology 2017/18
6785
Concise Guide to Pharmacology 2019/20
6785
Concise Guide to Pharmacology 2021/22
6785
Concise Guide to Pharmacology 2023/24
6785
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMINOX3
DrugMAP Approved Drugs
DMINOX3
Guide to Pharmacology
6785
LINCS compound set
10488-114
NIH Approved Oncology Drugs
112141, 92764772
NIH Mechanistic Set
NPC Screening Collection
TargetMol Bioactive Compound Library
T1270
Tocris Bioactive Compound Library
1257
Tocriscreen Total
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
824.4
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
9
Aromatic Ring Count
3
cLogP
3.52
TPSA
171.17
Fraction CSP3
0.57
Chiral centers
10.0
Largest ring
9.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Microtubule
Microtubule/Tubulin
Primary Target
Microtubules
MOA
Microtubule Associated
Therapeutic Class
Anticancer Agents
Pathway
Cytoskeletal Signaling
Source data