General
Preferred name
vincristine
Synonyms
Leurocristine ()
VINCRISTINE SULFATE ()
22-Oxovincaleukoblastine sulfate ()
Leurocristine sulfate ()
22-Oxovincaleukoblastine ()
Oncovine ()
Vincrystine ()
Vinkristin ()
Onkovin ()
Oncovin ()
VCR sulfate ()
Alkaloid extracted from Vinca rosea Linn ()
Vincasar ()
Vincrex ()
Kyocristine ()
Vincristine (free base) ()
NSC-67574 ()
Marqibo ()
Vincristine Sulfate Pfs ()
LILLY-37231 ()
37231 ()
Marqibo Kit ()
Vincrisul ()
Vincristini sulfas ()
Vincasar Pfs ()
Vincristine sulphate ()
Vincristine sulfate liposome ()
Novopharm ()
Vincaleukoblastine, 22-oxo- ()
Tecnocris ()
Oncotcs ()
Leucristine ()
Vincristin ()
P&D ID
PD009969
CAS
28379-27-3
57-22-7
2068-78-2
Tags
natural product
drug
available
Drug indication
Antineoplastic
Acute lymphoblastic leukaemia
Drug Status
approved
Max Phase
Phase 4
First approval
1963
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A pan tubulin inhibitor, isolated from Catharanthus roseus (the Madagascar periwinkle, formerly Vinca rosea). Marketed formulations contain vincristine sulfate (PubChem CID 249332). (GtoPdb)
DESCRIPTION p53 inhibitor. Also aryl hydrocarbon receptor agonist (Tocris Bioactive Compound Library)
DESCRIPTION Disrupts microtubules (Tocriscreen Total)
DESCRIPTION The attenuating effect of VC in Vincristine-induced nociceptive painful sensation may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action. (BOC Sciences Bioactive Compounds)
Cell lines
74
Organisms
2
Compound Sets
18
AdooQ Bioactive Compound Library
A10973
BOC Sciences Bioactive Compounds
vincristine-cas-57-22-7-item-464460
ChEMBL Approved Drugs
CHEMBL501867
CHEMBL90555
ChEMBL Drugs
CHEMBL501867
CHEMBL90555
Concise Guide to Pharmacology 2017/18
6785
Concise Guide to Pharmacology 2019/20
6785
Concise Guide to Pharmacology 2021/22
6785
Concise Guide to Pharmacology 2023/24
6785
DrugMAP
DMINOX3
DrugMAP Approved Drugs
DMINOX3
Guide to Pharmacology
6785
LINCS compound set
10488-114
NIH Approved Oncology Drugs
112141, 92764772
NIH Mechanistic Set
NPC Screening Collection
TargetMol Bioactive Compound Library
T1270
Tocris Bioactive Compound Library
1257
Tocriscreen Total
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
824.4
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
9
Aromatic Ring Count
3
cLogP
3.52
TPSA
171.17
Fraction CSP3
0.57
Chiral centers
10.0
Largest ring
9.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
Target
Microtubule
Primary Target
Microtubules
MOA
Microtubule Associated
Therapeutic Class
Anticancer Agents
Source data