General
Preferred name
HYDROXYZINE
Synonyms
Hydroxizine Chloride ()
Vistaril ()
Ucerax ()
HYDROXYZINE PAMOATE ()
Hydroxyzine (D4 dihydrochloride) ()
Hydroxyzine free base ()
Hydroxyzine embonate ()
Bobsule ()
Equipose ()
Hydroxyzine 2HCl ()
Hydroxyzine, (R) ()
Hydroxyzine dihydrochloride ()
Vistaril Pamoate10246-75-0 ()
HYDROXYZINE HYDROCHLORIDE ()
Hydroxyzine (dihydrochloride) ()
Hydroxyzine (pamoate) ()
ALAMON ()
ATARAX ()
ATARAX DIHYDROCHLORIDE ()
ATERAX ()
ATRANINE A ()
DURRAX ()
ORGATRAX ()
UCERAX ()
VISTARIL ()
Hy-Pam "25" ()
NSC-757063 ()
Hy-pam ()
Tran-q ()
Tranquizine ()
Hidroxizina ()
Ataraxoid ()
NSC-169188 ()
Marex ()
U.c.b-4492 ()
Hydroxyzine-d8 (hydrochloride) ()
P&D ID
PD009966
CAS
10246-75-0
68-88-2
2192-20-3
14729-22-7
1244-76-4
1808202-93-8
Tags
available
drug
Approved by
FDA
First approval
1956
1959
Drug indication
Urticaria
Anxiety disorder
Anxiety
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Hydroxyzine pamoate is a histamine receptor H1 antagonist, one of the salt forms of Hydroxyzine, soluble in dimethyl formamide and chloroform but insoluble in water and alcohol[1].
PRICE 35
PRICE 29
DESCRIPTION Hydroxyzine is a first-generation diphenylmethane and piperazine class antihistamine. Second-generation antihistamine is one of the metabolites of hydroxyzine, but cetirizine differs in that it appears not to cross the blood-brain barrier to any significant level. (GtoPdb)
PRICE 29
DESCRIPTION Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. ;Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder[1].
DESCRIPTION Hydroxyzine pamoate, a derivative of hydroxyzine, is a histamine H1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probably effective in the treatment of insomnia and withdrawal treatment. (BOC Sciences Bioactive Compounds)
DESCRIPTION Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. (TargetMol Bioactive Compound Library)
DESCRIPTION Hydroxyzine is an antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria. (Enamine Bioactive Compounds)
DESCRIPTION Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. (TargetMol Bioactive Compound Library)
DESCRIPTION Hydroxyzine (Hydroxyzine free base) is an antagonist of histamine H1-receptor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
29
BOC Sciences Bioactive Compounds
hydroxyzine-pamoate-cas-10246-75-0-item-53187
Cayman Chemical Bioactives
24039
30739
ChEMBL Approved Drugs
CHEMBL1200467
CHEMBL3186993
CHEMBL896
ChEMBL Drugs
CHEMBL1200467
CHEMBL3186993
CHEMBL896
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00557
DrugBank Approved Drugs
DB00557
DrugCentral
1400
DrugCentral Approved Drugs
1400
DrugMAP
DMF8Y74
DrugMAP Approved Drugs
DMF8Y74
DrugMatrix
Enamine Bioactive Compounds
EBC-13167
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0000873
Guide to Pharmacology
7199
JUMP-MOA Compound Set
3658
Ki Database
Hydroxyzine
Hydroxyzine, (R)
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL896
MedChem Express Bioactive Compound Library
HY-B0895
HY-B0548A
HY-B0548
NCATS Inxight Approved Drugs
30S50YM8OG
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
hydroxyzine-pamoate
hydroxyzine-2hcl
TargetMol Bioactive Compound Library
T0053
T2200
T20884
The Spectrum Collection
External IDs
145
Properties
(calculated by RDKit )
Molecular Weight
374.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
3.06
TPSA
35.94
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
H1 receptor
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
MOA
antihistamine
Therapeutic Class
Hypnotics and Sedatives
Solubility
10 mM in H2O
Recommended Cell Concentration
100 nM
Source data