General
Preferred name
DOXAPRAM
Synonyms
AHR-619 ()
Doxapram hydrochloride hydrate ()
Doxapram HCl ()
Doxapram hydrochloride monohydrate ()
Doxapram hydrochloride ()
Doxapram H2OxHCl ()
Doxapram (hydrochloride hydrate) ()
Stimulexin ()
Dopram ()
NSC-760347 ()
NSC-170958 ()
Docatone ()
doxapram ()
P&D ID
PD009963
CAS
7081-53-0
309-29-5
113-07-5
Tags
natural product
drug
available
Approved by
FDA
First approval
1965
Drug Status
approved
vet_approved
Drug indication
Stimulant (respiratory)
Respiratory disease
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Doxapram is an analeptic, ie it is a central nervous system stimulant.
Marketed formulations may contain doxapram hydrochloride (PubChem CID 64647). (GtoPdb)
DESCRIPTION Doxapram is a respiratory stimulant with analeptic activity. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. It has been used as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease. (BOC Sciences Bioactive Compounds)
Compound Sets
25
BOC Sciences Bioactive Compounds
doxapram-cas-309-29-5-item-65721
Cayman Chemical Bioactives
23794
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL3989519
CHEMBL1754
ChEMBL Drugs
CHEMBL3989519
CHEMBL1754
DrugBank
DB00561
DrugBank Approved Drugs
DB00561
DrugCentral
953
DrugCentral Approved Drugs
953
DrugMAP
DMCYANK
DrugMAP Approved Drugs
DMCYANK
Enamine BioReference Compounds
Guide to Pharmacology
7169
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1754
Mcule NIBR MoA Box Subset
MCULE-9853713128
MedChem Express Bioactive Compound Library
HY-B0551A
NCATS Inxight Approved Drugs
94F3830Q73
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
doxapram-hcl
doxapram
TargetMol Bioactive Compound Library
T0038
The Spectrum Collection
External IDs
71
Properties
(calculated by RDKit )
Molecular Weight
378.23
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
3.17
TPSA
32.78
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
MOA
chemoreceptor agonist
Target
Potassium channel subfamily K member 3
Potassium channel subfamily K member 9
TASK-1
TASK-1/TASK-3 heterodimeric
TASK-3
Potassium Channel
Member status
member
Therapeutic Class
Central Nervous System Stimulants
Solubility
Soluble in DMSO, not in water.
Source data