General
Preferred name
ceftriaxone
Synonyms
Disodium ceftriaxone ()
CEFTRIAXONE SODIUM TRIHYDRATE ()
Ceftriaxone disodium hemiheptahydrate ()
Ceftriaxone sodium hydrate ()
Ceftriaxone disodium salt hemi (heptahydrate) ()
Ro 13-9904 (free acid) ()
Ceftriaxona ()
Ceftriaxon ()
RO-13-9904/001 ()
Rocephin ()
Ceftriaxone (as sodium) ()
Ceftriaxone disodium salt hemiheptahydrate ()
Ceftriaxone sodium anhydrous ()
Ro 13-9904 ()
Cefraden ()
Ceftriaxone sodium sesquaterhydrate ()
Sodium ceftriaxone, anhydrous ()
Rocefin ()
RO-13-9904 ()
Megion ()
Ceftriaxone disodium salt ()
Ceftriaxone sodium component of rocephin kit ()
Ceftriaxone sodium ()
P&D ID
PD009960
CAS
73384-59-5
104376-79-6
Tags
available
drug
covalent binder
Approved by
FDA
First approval
1984
Drug indication
osteomyelitis
infection
Bacterial infection
Drug Status
investigational
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ceftriaxone is a cephalosporin antibacterial. (GtoPdb)
DESCRIPTION Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum ¦Â-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3¦Â with IC50 value of 0.78 ¦ÌM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis[1][2][3][4][5][6][7].
PRICE 286
PRICE 29
DESCRIPTION Ceftriaxone is a novel cephalosporin antibiotic with antimicrobial activity against most Gram-positive and Gram-negative bacteria.Ceftriaxone also exhibits anti-inflammatory and antioxidant activity. (TargetMol Bioactive Compound Library)
DESCRIPTION Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
19
ChEMBL Approved Drugs
CHEMBL161
CHEMBL6067656
ChEMBL Drugs
CHEMBL161
CHEMBL6067656
CovBinderInPDB
CBR001547
CBR001548
CBR002492
CBR002493
Drug Repurposing Hub
DrugBank
DB01212
DrugBank Approved Drugs
DB01212
DrugCentral
564
DrugCentral Approved Drugs
564
DrugMAP
DMCEW64
DrugMAP Approved Drugs
DMCEW64
Guide to Pharmacology
5326
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL161
MedChem Express Bioactive Compound Library
HY-B0712
NCATS Inxight Approved Drugs
75J73V1629
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
ceftriaxone-sodium-trihydrate
TargetMol Bioactive Compound Library
T75295
T1223
External IDs
263
Properties
(calculated by RDKit )
Molecular Weight
554.05
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
2
cLogP
-1.61
TPSA
214.96
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.1
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
Aurora Kinase
GSK-3
Fungal
Pathway
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
PI3K/Akt/mTOR
Stem Cell/Wnt
Member status
virtual
MOA
Antibacterial
Antibiotic
organic anion transporter inhibitor
bacterial cell wall synthesis inhibitor
Disease Area
infectious disease, otolaryngology
Indication
gonorrhea, pneumonia, otitis, skin infections, urinary tract infections, pelvic inflammatory disease, bacterial septicemia, bone and joint infections, intra-abdominal infections, meningitis, surgical prophylaxis
Therapeutic Class
Antibiotics
Source data