General
Preferred name
METIPRANOLOL
Synonyms
METIPRANOLOL HYDROCHLORIDE ()
Betamann ()
VUAB-6453 ()
OptiPranolol ()
Glauline ()
BM-01004 ()
D,l-metipranolol ()
BM01.004 ()
BM-01.004 ()
VUAB6453 ()
VUAB6453 (SPOFA) ()
Metipranolol HCl ()
Metipranolol (hydrochloride) ()
P&D ID
PD009959
CAS
22664-55-7
36592-77-5
Tags
available
drug
Approved by
FDA
First approval
1989
Drug Status
approved
withdrawn
Drug indication
Antihypertensive (beta-blocker, ophthalmic)
Open-angle glaucoma
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Metipranolol is a β-blocker. The drug's active metabolite is desacetylmetipranolol (CHEMBL1201363). (GtoPdb)
Compound Sets
17
Cayman Chemical Bioactives
34089
24003
ChEMBL Approved Drugs
CHEMBL1291
CHEMBL1200947
ChEMBL Drugs
CHEMBL1291
CHEMBL1200947
DrugBank
DB01214
DrugBank Approved Drugs
DB01214
DrugCentral
1779
DrugCentral Approved Drugs
1779
DrugMAP
DMJMVKI
DrugMAP Approved Drugs
DMJMVKI
DrugMatrix
Guide to Pharmacology
7239
MedChem Express Bioactive Compound Library
HY-121567
HY-16316
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
metipranolol
TargetMol Bioactive Compound Library
T8899
Withdrawn 2.0
w16
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
309.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
2.27
TPSA
67.79
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??-adrenergic receptor
Adrenergic Receptor
ATC
S01ED04
Toxicity type
hematological
Therapeutic Class
Antihypertensive Agents
Source data