General
Preferred name
RIFAXIMIN
Synonyms
Rifaximin (Xifaxan) ()
Rifacol ()
Xifaxanta ()
Xifaxan ()
Normix ()
Rifamycin l 105 ()
Rifaxidin ()
Targaxan ()
L-105 ()
Xifaxsan ()
NSC-758957 ()
P&D ID
PD009955
CAS
80621-81-4
Tags
natural product
drug
available
Approved by
FDA
First approval
2004
Drug Status
investigational
approved
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This binding blocks translocation, which stops transcription.
DESCRIPTION
Rifaximin is a semisynthetic derivative of rifamycin and belongs to the ansamycin group of antibacterial compounds . It has broad spectrum activity against Gram-positive and Gram-negative bacteria.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
785.35
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
5
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
4
cLogP
6.16
TPSA
198.38
Fraction CSP3
0.44
Chiral centers
9.0
Largest ring
24.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Inhibitor of transcription by by binding to the β-subunit of bacterial RNA polymerase, also activator of NR1I2
RNA synthesis inhibitor
Inhibitor of transcription by by binding to the β-subunit of bacterial RNA polymerase, also activator of NR1I2
Indication
diarrhea, irritable bowel syndrome, hepatic encephalopathy (HE)
Pathway
Anti-infection
Cell Cycle/DNA Damage
Target
antibiotic
Bacterial
DNA/RNA Synthesis
Source data
