General
Preferred name
Levacetylmethadol
Synonyms
levomethadyl acetate ()
Levomethadyl acetate ()
LEVOMETHADYL ACETATE HYDROCHLORIDE ()
LAAM ()
Levo-alphacetylmethadol ()
Levoacetyl methadol ()
Levacetilmetadol ()
LAA-M ()
Orlaam ()
MK-790 ()
Levomethadyl acetate hcl ()
MK790 ()
Levacetylmethadol hydrochloride ()
P&D ID
PD009951
CAS
1477-40-3
34433-66-4
43033-72-3
Tags
prodrug
drug
Approved by
FDA
EMA
First approval
1993
Drug indication
Opioid dependence
drug dependence
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
METABOLISM
Levomethadyl acetate is demethylated to nor-levomethadyl acetate which is again demethylated to dinor-levomethadyl acetate. This extensive first pass metabolism produces 2 metabolites that are more active than the parent drug.
DESCRIPTION
Levomethadyl is a opioid analgesic.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
353.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
4.65
TPSA
29.54
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
N07BC03
Therapeutic Class
Analgesics
Source data
