General
Preferred name
ENCAINIDE
Synonyms
ENCAINIDE HYDROCHLORIDE ()
MJ9067 ()
Enkaid ()
MJ-9067 ()
Encainide hcl ()
MJ 9067-1 ()
MJ-9067-1 ()
P&D ID
PD009950
CAS
66778-36-7
37612-13-8
66794-74-9
Tags
available
drug
First approval
1987
1986
Drug Status
investigational
approved
withdrawn
Drug indication
Heart arrhythmia
Cardiac Depressant (anti-arrhythmic)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated sodium channels and slows conduction within the His-Purkinje system and myocardium. It has antifibrillatory activity. It was developed by Bristol-Myers Squibb and is no longer used because of its frequent proarrhythmic side effects.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
352.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
4.36
TPSA
41.57
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
C01BC08
Toxicity type
cardiovascular
Therapeutic Class
Antiarrhythmic Agents
Solubility
H2O: >25 mg/mL
Source data
