General
Preferred name
DIPHENIDOL
Synonyms
.Alpha.,.alpha.-diphenyl-1-piperidinebutanol ()
DIPHENIDOL HYDROCHLORIDE ()
Diphenidol HCl ()
Difenidol hydrochloride ()
Diphenidol (hydrochloride) ()
DIPHENIDOL PAMOATE ()
NSC-23012 ()
Cephadol ()
SK-478-A ()
SK&F 478-A ()
Vontrol ()
SK&F-478-A ()
SK-478 ()
SK&F-478 ()
SK&F 478 ()
Difenidol ()
SK&F-478-J ()
SK&F 478-J ()
Diphenidol embonate ()
Diphenidol-d10 ()
P&D ID
PD009949
CAS
3254-89-5
972-02-1
19-11-4
26363-46-2
7491-12-5
2928181-97-7
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1967
Drug indication
Nausea
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea[1][2][3][4][5].
PRICE 29
DESCRIPTION Diphenidol is a muscarinic antagonist , antiemetic and antivertigo drug. (GtoPdb)
DESCRIPTION Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo. (BOC Sciences Bioactive Compounds)
DESCRIPTION Diphenidol HCl is a non-selective muscarinic acetylcholine receptor antagonist. It is employed as an antiemetic and as an antivertigo agent. (Enamine Bioactive Compounds)
DESCRIPTION Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug. (TargetMol Bioactive Compound Library)
Compound Sets
26
BOC Sciences Bioactive Compounds
diphenidol-hydrochloride-cas-3254-89-5-item-84-90198
Cayman Chemical Bioactives
18674
33979
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1529
CHEMBL936
ChEMBL Drugs
CHEMBL1529
CHEMBL936
CHEMBL2105784
Concise Guide to Pharmacology 2023/24
7163
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01231
DrugBank Approved Drugs
DB01231
DrugCentral
313
DrugCentral Approved Drugs
313
DrugMAP
DMHPWOM
DrugMAP Approved Drugs
DMHPWOM
Enamine Bioactive Compounds
EBC-03840
Enamine BioReference Compounds
Guide to Pharmacology
7163
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1529
CHEMBL936
MedChem Express Bioactive Compound Library
HY-A0082
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
diphenidol-hcl
TargetMol Bioactive Compound Library
T0862
Withdrawn 2.0
DB01231
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
309.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
4.19
TPSA
23.47
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
Muscarinic M1 Receptor Ligands
Muscarinic M3 Receptor Ligands
Muscarinic M4 Receptor Ligands
acetylcholine receptor agonist
Target
Muscarinic acetylcholine receptor M1
mAChR
Sodium Channel
CHRM1, CHRM2, CHRM3, CHRM4
AChR
Member status
member
Indication
vertigo
ATC
A
Pathway
Membrane Transporter/Ion Channel
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data