General
Preferred name
METOCLOPRAMIDE
Synonyms
METOCLOPRAMIDE HYDROCHLORIDE ()
MetoclopraMide HCl ()
Maxolon ()
Metoclopramide monohydrochloride monohydrate ()
METOCLOPRAMIDE HYDROCHLORIDE HYDRATE ()
5-Chloro-2-methoxyprocainamide ()
Metoclopramide monohydrochloride ()
Clorpa, Gimoti, Maxolon, Reglan ()
AHR-3070-C ()
Metoclomex ()
Gimoti ()
Primperan ()
Mygdalon ()
Metoclopramide hydrochloride monohydrate ()
Metoclopramide hcl monohydrate ()
Metoclopramide Intensol ()
Gastrobid Continus ()
Gastromax ()
Metox ()
NSC-757117 ()
Metipamid ()
Clopra ()
Parmid ()
"clopra-""yellow""" ()
Reglan ()
Gastrese L.A. ()
Reglan Odt ()
Metoclopramidi hydrochloridum ()
Metoclopramide dihydrochloride monohydrate ()
Clopra-"Yellow" ()
Gastroflux ()
Maxolon Sr ()
Metramid ()
Metozolv Odt ()
Elieten ()
Methoxyclopramide ()
Terperan ()
Metoclopramide (hydrochloride) ()
Metoclopramide-d3 ()
P&D ID
PD009947
CAS
54143-57-6
7232-21-5
364-62-5
49625-23-2
2576-84-3
1216522-89-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1979
Drug Status
investigational
approved
Drug indication
Anti-Emetic
Nausea
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Metoclopramide is a promarily dopamine receptor antagonist, but it also exhibits mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. (GtoPdb)
DESCRIPTION 5-HT3 Serotonin receptor antagonist; D2 dopamine receptor antagonist; anti-emetic (LOPAC library)
Compound Sets
33
AdooQ Bioactive Compound Library
A15161
Axon Medchem Screening Library
3378
Cayman Chemical Bioactives
23360
28885
ChEMBL Approved Drugs
CHEMBL1200940
CHEMBL86
ChEMBL Drugs
CHEMBL1200940
CHEMBL86
Concise Guide to Pharmacology 2017/18
241
Concise Guide to Pharmacology 2019/20
241
Concise Guide to Pharmacology 2021/22
241
Concise Guide to Pharmacology 2023/24
241
Drug Repurposing Hub
DrugBank
DB01233
DrugBank Approved Drugs
DB01233
DrugCentral
1782
DrugCentral Approved Drugs
1782
DrugMAP
DMFA5MY
DrugMAP Approved Drugs
DMFA5MY
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101629
Guide to Pharmacology
241
Ki Database
METOCLOPRAMIDE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL86
Mcule NIBR MoA Box Subset
MCULE-8566255889
NCATS Inxight Approved Drugs
L4YEB44I46
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
metoclopramide-hcl
metoclopramide-hydrochloride-hydrate
metoclopramide
TargetMol Bioactive Compound Library
T1069
T8385
T4616
The Spectrum Collection
External IDs
81
Properties
(calculated by RDKit )
Molecular Weight
299.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
2.0
TPSA
67.59
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT
mAChR
dopamine
Dopamine D2
CHRM1, DRD2, HTR3A, HTR3B, HTR4
D2/5-HT3 antagonist
5-HT Receptor,Dopamine Receptor
MOA
Dopamine Receptor
Dopamine Receptor Antagonists
dopamine receptor antagonist, serotonin receptor antagonist
Member status
member
Indication
gastroparesis, nausea, vomiting
Therapeutic Class
Antiemetics
Source data