General
Preferred name
METOCLOPRAMIDE
Synonyms
METOCLOPRAMIDE HYDROCHLORIDE ()
Maxolon ()
MetoclopraMide HCl ()
5-Chloro-2-methoxyprocainamide ()
Metoclopramide monohydrochloride monohydrate ()
Metoclopramide monohydrochloride ()
Clorpa, Gimoti, Maxolon, Reglan ()
METOCLOPRAMIDE HYDROCHLORIDE HYDRATE ()
Metoclopramide (hydrochloride) ()
Primperan ()
Gastromax ()
Metipamid ()
Metramid ()
Metoclopramide hcl monohydrate ()
Gastroflux ()
AHR-3070-C ()
Reglan Odt ()
Maxolon Sr ()
Gastrese L.A. ()
Metox ()
Gastrobid Continus ()
Parmid ()
Gimoti ()
Metoclomex ()
Metozolv Odt ()
"clopra-""yellow""" ()
Metoclopramide hydrochloride monohydrate ()
Mygdalon ()
Metoclopramide Intensol ()
NSC-757117 ()
Metoclopramidi hydrochloridum ()
Metoclopramide dihydrochloride monohydrate ()
Reglan ()
Clopra ()
Metoclopramida ()
Terperan ()
Clopra-"Yellow" ()
Methoxyclopramide ()
Elieten ()
Metoclopramide-d3 ()
P&D ID
PD009947
CAS
54143-57-6
7232-21-5
49625-23-2
364-62-5
2576-84-3
1216522-89-2
Tags
available
drug
Approved by
FDA
First approval
1979
Drug indication
Nausea
post operative nausea and vomiting
Myelodysplastic syndrome
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
PRICE 29
DESCRIPTION Metoclopramide is a promarily dopamine receptor antagonist, but it also exhibits mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist activity. (GtoPdb)
PRICE 29
DESCRIPTION 5-HT3 Serotonin receptor antagonist; D2 dopamine receptor antagonist; anti-emetic (LOPAC library)
DESCRIPTION Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic. (TargetMol Bioactive Compound Library)
DESCRIPTION Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) is a dopamine D2 antagonist that is a drug used for digestive dysfunction. It acts as an anti-emetic (TargetMol Bioactive Compound Library)
DESCRIPTION Metoclopramide is an antiemetic agent and dopamine D2 antagonist. It is used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. (Enamine Bioactive Compounds)
DESCRIPTION Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. (TargetMol Bioactive Compound Library)
Compound Sets
34
AdooQ Bioactive Compound Library
A15161
Axon Medchem Screening Library
3378
Cayman Chemical Bioactives
23360
39844
28885
ChEMBL Approved Drugs
CHEMBL1200940
CHEMBL86
ChEMBL Drugs
CHEMBL1200940
CHEMBL86
Concise Guide to Pharmacology 2017/18
241
Concise Guide to Pharmacology 2019/20
241
Concise Guide to Pharmacology 2021/22
241
Concise Guide to Pharmacology 2023/24
241
Drug Repurposing Hub
DrugBank
DB01233
DrugBank Approved Drugs
DB01233
DrugCentral
1782
DrugCentral Approved Drugs
1782
DrugMAP
DMFA5MY
DrugMAP Approved Drugs
DMFA5MY
DrugMatrix
Enamine Bioactive Compounds
EBC-04213
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101629
Guide to Pharmacology
241
Ki Database
METOCLOPRAMIDE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL86
Mcule NIBR MoA Box Subset
MCULE-8566255889
NCATS Inxight Approved Drugs
L4YEB44I46
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
metoclopramide-hcl
metoclopramide-hydrochloride-hydrate
metoclopramide
TargetMol Bioactive Compound Library
T1069
T8385
T4616
The Spectrum Collection
External IDs
87
Properties
(calculated by RDKit )
Molecular Weight
299.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
2.0
TPSA
67.59
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Target
5-HT
dopamine
mAChR
5-HT Receptor
CHRM1, DRD2, HTR3A, HTR3B, HTR4
D2/5-HT3 antagonist
5-HT Receptor,Dopamine Receptor
MOA
Dopamine Receptor
Dopamine Receptor Antagonists
dopamine receptor antagonist, serotonin receptor antagonist
Member status
member
Indication
gastroparesis, nausea, vomiting
Pathway
GPCR/G protein
Neuroscience
Therapeutic Class
Antiemetics
Source data