General
Preferred name
BEPRIDIL
Synonyms
BEPRIDIL HYDROCHLORIDE ()
CERM 1978 ()
Bepridil hydrochloride ()
Bepridil (hydrochloride hydrate) ()
(±)-Bepridil (hydrochloride hydrate) ()
Org 5730 (hydrochloride hydrate) ()
Bepridil hydrochloride hydrate ()
Bepadin ()
Vascor ()
Cordium ()
Unicordium ()
NSC-758390 ()
CERM-1978 ()
Bepridil (hydrochloride) ()
P&D ID
PD009942
CAS
74764-40-2
68099-86-5
64706-54-3
49571-05-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1990
Drug Status
approved
withdrawn
Drug indication
Vasodilator
Chronic/stable angina
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The drug bepridil is a racemic mixture of two enantiomers for the 2R as CID 16048570 and 2S as CID 445143. The structure shown here represents the mixture. (GtoPdb)
DESCRIPTION Allosteric potentiator of alpha7, alpha4beta2 and alpha4beta4 nAChRs (Tocris Bioactive Compound Library)
DESCRIPTION Non-selective calcium channel blocker (Tocriscreen Plus)
DESCRIPTION Non-selective Ca2+ channel blocker which stimulates the binding of 1,4-dihydropyridine-based drugs to Ca2+ channels; anti-anginal (LOPAC library)
DESCRIPTION Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation. (BOC Sciences Bioactive Compounds)
DESCRIPTION Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
3
Compound Sets
32
BOC Sciences Bioactive Compounds
bepridil-hydrochloride-cas-68099-86-5-item-196682
bepridil-hydrochloride-hydrate-cas-74764-40-2-item-97916
Cayman Chemical Bioactives
19645
ChEMBL Approved Drugs
CHEMBL1008
CHEMBL1200382
ChEMBL Drugs
CHEMBL1008
CHEMBL1200382
Concise Guide to Pharmacology 2017/18
2337
Concise Guide to Pharmacology 2019/20
2337
Concise Guide to Pharmacology 2021/22
2337
Concise Guide to Pharmacology 2023/24
2337
Drug Repurposing Hub
DrugBank
DB01244
DrugBank Approved Drugs
DB01244
DrugCentral
342
DrugCentral Approved Drugs
342
DrugMAP
DM0RKS4
DrugMAP Approved Drugs
DM0RKS4
DrugMatrix
Guide to Pharmacology
2337
JUMP-Target 1 Compound Set
2351
Ki Database
Bepridil
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1008
MedChem Express Bioactive Compound Library
HY-103315
HY-16952A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
bepridil-hydrochloride
TargetMol Bioactive Compound Library
T5391
The Spectrum Collection
Tocris Bioactive Compound Library
4117
Tocriscreen Plus
4117
VGSC-DB
NA0013
Withdrawn 2.0
DB01244
External IDs
72
Properties
(calculated by RDKit )
Molecular Weight
366.27
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
2
cLogP
4.83
TPSA
15.71
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Calcium Channel
KCNQ4
TNNC1
Primary Target
Non-selective Cav Channels
MOA
Blocker
calcium channel blocker
Indication
angina pectoris
ATC
C08EA02
Therapeutic Class
Antiarrhythmic Agents
VGSC Target
Nav1.5
Source data