General
Preferred name
DECAMETHONIUM
Synonyms
DECAMETHONIUM BROMIDE ()
Decamethonium dibromide ()
Decacuran ()
Syncurine ()
Decamethonium (Bromide) ()
Decamethonium diiodide ()
Bromuro de decametonio ()
Bromure de decamethonium ()
NSC-23004 ()
Decamethonium ion ()
Decamethonium cation ()
P&D ID
PD009941
CAS
541-22-0
55524-45-3
156-74-1
Tags
available
drug
Approved by
FDA
First approval
1982
1975
Drug indication
Muscle spasm
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.;Target: nAChR;Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release [1].
DESCRIPTION Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent. (BOC Sciences Bioactive Compounds)
DESCRIPTION Nicotinic acetylcholine receptor partial agonist; depolarizing neuromuscular blocker (LOPAC library)
DESCRIPTION Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
22
BOC Sciences Bioactive Compounds
decamethonium-bromide-cas-541-22-0-item-84-123678
Cayman Chemical Bioactives
24907
ChEMBL Approved Drugs
CHEMBL1134
CHEMBL1190
ChEMBL Drugs
CHEMBL1134
CHEMBL1190
Drug Repurposing Hub
DrugBank
DB01245
DrugBank Approved Drugs
DB01245
DrugCentral
789
DrugCentral Approved Drugs
789
DrugMAP
DMSBRUW
DrugMAP Approved Drugs
DMSBRUW
DrugMatrix
Ki Database
Decamethonium
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1134
CHEMBL1190
MedChem Express Bioactive Compound Library
HY-B0570
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
decamethonium-bromide
TargetMol Bioactive Compound Library
T0818
The Spectrum Collection
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
258.3
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
11
Ring Count
0
Aromatic Ring Count
0
cLogP
3.52
TPSA
0.0
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Nicotinic
Target
AChE
nAChR
ACHE, CHRNA2
AChR
Indication
muscle relaxant
MOA
acetylcholine receptor agonist
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Therapeutic Class
Neuromuscular Depolarizing Agents
Source data