General
Preferred name
alimemazine
Synonyms
Temaril ()
Alimemazine Tartrate ()
Vallergan Fte ()
Vallergan ()
TRIMEPRAZINE TARTRATE ()
trimeprazine ()
Alimemazine D6 ()
Trimeprazine D6 ()
Methylpromazine Tartrate ()
Trimeprazine hemitartrate ()
Alimemazine hemitartrate ()
Trimeprazine Tartrate, Methylpromazine Tartrate ()
METHYLPROMAZINE ()
BAYER-1219 ()
Dl-trimeprazine ()
Alimemazina ()
Alimemazine ()
RP-6549 ()
Panectyl ()
Theralene ()
NSC-17475 ()
NSC-757358 ()
Repeltin ()
Trimeprazine (tartrate) ()
P&D ID
PD009940
CAS
4330-99-8
84-96-8
1175-88-8
14101-45-2
41375-66-0
Tags
available
drug
Approved by
FDA
Drug indication
Allergic rhinitis
allergic disease
Drug Status
vet_approved
approved
Max Phase
4.0
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Alimemazine is a phenothiazine derivative antihistamine. (GtoPdb)
PRICE 39
DESCRIPTION Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic ¦Â-cells in mice and improves diabetes in mice[1][2][3].
DESCRIPTION Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
21
Cayman Chemical Bioactives
33891
ChEMBL Approved Drugs
CHEMBL829
CHEMBL3989885
ChEMBL Drugs
CHEMBL829
CHEMBL3989885
DrugBank
DB01246
DrugBank Approved Drugs
DB01246
DrugCentral
2749
DrugCentral Approved Drugs
2749
DrugMAP
DMEMV9D
DrugMAP Approved Drugs
DMEMV9D
DrugMatrix
Guide to Pharmacology
7237
Ki Database
Trimeprazine
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1713082
MedChem Express Bioactive Compound Library
HY-12752A
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
alimemazine-tartrate
TargetMol Bioactive Compound Library
T3282
The Spectrum Collection
External IDs
77
Properties
(calculated by RDKit )
Molecular Weight
298.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.49
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
Influenza Virus
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Anti-infection
Therapeutic Class
Antihistamines
Source data