General
Preferred name
olsalazine
Synonyms
OLSALAZINE SODIUM ()
Dipentum ()
Olsalazine disodium ()
Olsalazine (Disodium) ()
Olsalazine disodium salt ()
CJ 91B ()
Disodium azodisalicylate ()
Azodisal Sodium ()
ADS ()
Sodium Azodisalicylate ()
CJ-91B ()
Sodium olsalazine ()
C. i. mordant yellow 5 ()
Olsalazine (sodium salt) ()
Olsalazine-13C6 ()
P&D ID
PD009937
CAS
6054-98-4
15722-48-2
Tags
available
prodrug
drug
Drug Status
approved
Max Phase
Phase 4
Drug indication
Anti-Inflammatory (gastrointestinal)
First approval
1990
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine reduces the bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain. Olsalazine is thought to work like balsalazide, delivering mesalazine or 5-aminosalicylic acid past the small intestine to the large intestine to act on the site of disease.
Compound Sets
12
Cayman Chemical Bioactives
23661
33798
ChEMBL Approved Drugs
CHEMBL1201013
CHEMBL425
ChEMBL Drugs
CHEMBL1201013
CHEMBL425
Drug Repurposing Hub
DrugBank
DB01250
DrugBank Approved Drugs
DB01250
MedChem Express Bioactive Compound Library
HY-B0174
HY-B0174A
NCATS Inxight Approved Drugs
ULS5I8J03O
ReFrame library
Selleckchem Bioactive Compound Library
olsalazine-sodium
TargetMol Bioactive Compound Library
T1544
The Spectrum Collection
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
302.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.91
TPSA
139.78
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
1
azo_A(324)
[#7;!R]=[#7]
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Neuroscience
Anti-infection
GPCR/G protein
Target
COX
IF??
IF¦Ã
IFNG, TPMT
antibiotic
Leukotriene Receptor
MOA
COX inhibitor
cyclooxygenase inhibitor
Indication
ulcerative colitis
Source data