General
Preferred name
olsalazine
Synonyms
OLSALAZINE SODIUM ()
Dipentum ()
Olsalazine disodium ()
Olsalazine (Disodium) ()
Olsalazine (sodium salt) ()
CJ-91B ()
Disodium azodisalicylate ()
Azodisal Sodium ()
Olsalazine disodium salt ()
Sodium Azodisalicylate ()
ADS ()
Sodium olsalazine ()
CJ 91B ()
C. i. mordant yellow 5 ()
Olsalazina ()
Olsalazine-13C6 ()
P&D ID
PD009937
CAS
6054-98-4
15722-48-2
Tags
available
prodrug
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Ankylosing spondylitis
Ulcerative colitis
First approval
1990
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Olsalazine Disodium is an anti-inflammatory compound that works in inflammatory bowel disease and ulcerative colitis.
PRICE
29
PHARMACODYNAMICS
Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine reduces the bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain. Olsalazine is thought to work like balsalazide, delivering mesalazine or 5-aminosalicylic acid past the small intestine to the large intestine to act on the site of disease.
DESCRIPTION
Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].
DESCRIPTION
Olsalazine disodium (Dipentum) is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
302.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.91
TPSA
139.78
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
1
azo_A(324)
[#7;!R]=[#7]
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
COX
IFγ
IF¦Ã
IFNG, TPMT
Leukotriene Receptor
MOA
COX inhibitor
cyclooxygenase inhibitor
Indication
ulcerative colitis
Pathway
Immunology/Inflammation
Microbiology/virology
Neuroscience
Anti-infection
GPCR/G protein
Source data
