General
Preferred name
PALIPERIDONE
Synonyms
Ro-92670 ()
Invega Sustenna ()
9-hydroxyrisperidone ()
9-OH-risperidone ()
paliperidone ER, Torrent Pharmaceuticals ()
NSC-759623 ()
Ro-76477 ()
Invega ()
RO76477 ()
Risperidone impurity, 9-hydroxyrisperidone- ()
R-76477 ()
Xeplion ()
Trevicta ()
Paliperidone-d4 ()
P&D ID
PD009928
CAS
144598-75-4
130049-84-2
1020719-55-4
Tags
natural product
drug
available
Approved by
EMA
FDA
First approval
2006
Drug Status
approved
Drug indication
Schizophrenia
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Paliperidone is an atypical antipsychotic developed by Janssen Pharmaceutica. Chemically, paliperidone is primary active metabolite of the older antipsychotic risperidone (paliperidone is 9-hydroxyrisperidone). The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone.
DESCRIPTION Paliperidone is an atypical antipsychotic. Mechanistically it is a dopamine receptor and 5-HT2A receptor antagonist. (GtoPdb)
DESCRIPTION 5-HT2C inverse agonist; alpha2-adrenoceptor antagonist (Tocris Bioactive Compound Library)
Compound Sets
25
AdooQ Bioactive Compound Library
A10691
Cayman Chemical Bioactives
15556
28484
ChEMBL Approved Drugs
CHEMBL1621
ChEMBL Drugs
CHEMBL1621
DrugBank
DB01267
DrugBank Approved Drugs
DB01267
DrugCentral
4137
DrugCentral Approved Drugs
4137
DrugMAP
DM7NPJS
DrugMAP Approved Drugs
DM7NPJS
Enamine BioReference Compounds
Guide to Pharmacology
7258
JUMP-Target 1 Compound Set
115237
Ki Database
9-OH-risperidone
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1621
MedChem Express Bioactive Compound Library
HY-A0019
NCATS Inxight Approved Drugs
838F01T721
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Paliperidone(Invega)
TargetMol Bioactive Compound Library
T0076
Tocris Bioactive Compound Library
4493
VGSC-DB
NA0102
NA0103
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
426.21
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
3
cLogP
3.08
TPSA
84.39
Fraction CSP3
0.52
Chiral centers
1.0
Largest ring
6.0
QED
0.69
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
5-HT
??-adrenergic receptor
dopamine
H1 receptor
HTR2C
5-HT Receptor
Adrenergic Receptor
Dopamine Receptor
Primary Target
5-HT2A Receptors
MOA
Antagonist
VGSC Target
Nav1.5
Source data