General
Preferred name
VARENICLINE
Synonyms
VARENICLINE TARTRATE ()
CP 526555-18 ()
Champix tartrate ()
Chantix tartrate ()
Varenicline dihydrochloride ()
CP-526555 ()
Vareniclina ()
CP-526,555 ()
Chantix ()
Tyrvaya ()
CP-526555-18 ()
Champix ()
CP-526,555-18 ()
VARENICLINA ()
P&D ID
PD009927
CAS
375815-87-5
249296-44-4
Tags
available
drug
Approved by
FDA
First approval
2006
Drug Status
approved
Max Phase
4.0
Drug indication
smoking cessation
lung carcinoma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
METABOLISM Metabolism is limited (<10%). Most of the active compound is excreted by the kidneys (81%). A minor amount of varenicline is glucuronidated, oxidated, N-formylated, as well as conjugated to form a hexose.
DESCRIPTION Marketed formulations usually contain varenicline tartrate (PubChem CID 9906942). ChEMBL represents this compound without specified stereochemistry (see link above). (GtoPdb)
DESCRIPTION Varenicline tartrate is a nicotinic acetylcholine receptor partial agonist. It is used to treat nicotine addiction. (Enamine Bioactive Compounds)
DESCRIPTION KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) (Tocris Bioactive Compound Library)
Compound Sets
18
Axon Medchem Screening Library
1384
2074
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1076903
CHEMBL6067972
ChEMBL Drugs
CHEMBL1076903
CHEMBL6067972
Concise Guide to Pharmacology 2017/18
5459
Concise Guide to Pharmacology 2019/20
5459
Concise Guide to Pharmacology 2021/22
5459
Concise Guide to Pharmacology 2023/24
5459
Drug Repurposing Hub
DrugCentral
2808
DrugCentral Approved Drugs
2808
Enamine Bioactive Compounds
EBC-07819
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0002001
Guide to Pharmacology
5459
NCATS Inxight Approved Drugs
W6HS99O8ZO
ReFrame library
Tocris Bioactive Compound Library
3754
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
211.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
1.8
TPSA
37.81
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Neuronal acetylcholine receptor
alpha4/beta2
mAChR
CHRNA3, CHRNA4, CHRNA6, CHRNA7
a4ß2 partial agonist
MOA
nicotinic acetylcholine receptor agonist
AChR antagonist
Agonist
acetylcholine receptor agonist
Primary Target
Nicotinic (?4?2) Receptors
Pathway
Neuroscience
Indication
smoking cessation
Recommended Cell Concentration
10 uM
Source data