General
Preferred name
HYDRALAZINE
Synonyms
HYDRALAZINE HYDROCHLORIDE ()
Hydralazine HCl ()
Apresoline ()
Hydralazine (hydrochloride) ()
MC-1101 ()
Apressinum ()
Hydralazine hydrochloride component of hydroserpine plus (r-h-h) ()
Hydralazine hydrochloride component of apresoline-esidrix ()
Hydralazine hydrochloride component of ser-a-gen ()
Hydralazine hydrochloride component of cam-ap-es ()
Hydralazine hydrochloride component of hydra-zide ()
Dralzine ()
Hydralazine hydrochloride component of dralserp ()
Hydralazini hydrochloridum ()
Hydralazine hydrochloride component of -hydrochlorothiazide-reserpine ()
Hydralazine hydrochloride component of serpasil-apresoline ()
Hydralazine hydrochloride component of hydrap-es ()
Hydralazine hydrochloride component of unipres ()
Hydralazine hydrochloride component of apresazide ()
Hydralazine hydrochloride component of ser-ap-es ()
Hydralazine hydrochloride component of bidil ()
NSC-89394 ()
Hidralazina ()
Hydralazine polistirex ()
NSC-126699 ()
Hydralazine-d4 (hydrochloride) ()
P&D ID
PD009925
CAS
86-54-4
304-20-1
2749234-32-8
Tags
available
drug
Approved by
FDA
First approval
1953
Drug indication
Congestive heart failure
Hypertension
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Hydralazine is a hydrazinophthalazine class anti-hypertensiove drug.
Hydralazine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
Hydralazine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
PRICE
29
DESCRIPTION
Non-selective MAO-A/B inhibitor; antihypertensive
(LOPAC library)
DESCRIPTION
Hydralazine is an antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia. It may interfere with calcium transport in vascular smooth muscle to relax arteriolar smooth muscle and lower blood pressure.
(Enamine Bioactive Compounds)
DESCRIPTION
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
27
AdooQ Bioactive Compound Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
74
Molecular Weight
160.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
0.92
TPSA
63.83
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO-A/B
MOA
prolyl hydroxylase inhibitor
MAO inhibitor
Target
Ryanodine receptor 2
HIF/HIF Prolyl-Hydroxylase
MAO
AO
Apoptosis
Bcl-2 Family
Caspase
Potassium Channel
Therapeutic Class
Antihypertensive Agents
Pathway
Chromatin/Epigenetic
Metabolism
Neuroscience
Source data
