General
Preferred name
HYDRALAZINE
Synonyms
HYDRALAZINE HYDROCHLORIDE ()
Hydralazine HCl ()
Apresoline ()
Hydralazine (hydrochloride) ()
NSC-89394 ()
Hydralazini hydrochloridum ()
MC-1101 ()
Dralzine ()
Apressinum ()
NSC-126699 ()
Hydralazine polistirex ()
Hydralazine-d4 (hydrochloride) ()
P&D ID
PD009925
CAS
86-54-4
304-20-1
2749234-32-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1953
Drug Status
approved
Drug indication
Hypertension
Antihypertensive
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Hydralazine is a hydrazinophthalazine class anti-hypertensiove drug.
Hydralazine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
Hydralazine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
DESCRIPTION
Non-selective MAO-A/B inhibitor; antihypertensive
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
AdooQ Bioactive Compound Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
66
Molecular Weight
160.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
0.92
TPSA
63.83
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO-A/B
MOA
prolyl hydroxylase inhibitor
MAO inhibitor
Target
Ryanodine receptor 2
MAO
AO
Bcl-2 Family
Caspase
Potassium Channel
Pathway
Metabolism
Neuroscience
Apoptosis
Therapeutic Class
Antihypertensive Agents
Source data
