General
Preferred name
GLUCOSAMINE
Synonyms
Chitosamine hydrochloride ()
2-Amino-2-deoxy-glucose HCl ()
Chitosamine HCl ()
D-(+)-Glucosamine hydrochloride ()
GLUCOSAMINE HYDROCHLORIDE ()
2-Amino-2-deoxyglucose (hydrochloride) ()
2-Amino-2-deoxy-D-glucopyranose ()
2-Amino-2-deoxy-glucose HCl, Chitosamine HCl ()
D-Glucosamine Hydrochloride ()
Chitosamine ()
Glucosamina ()
Mediflex ()
Faximin ()
Dona ()
Tiocondramina ()
Glusartel ()
Glucosamine sulfate salt ()
Glucosamine sulf ()
Dolenio ()
GLUCOSAMINE SULFATE ()
Glucosamine (as hydrochloride) ()
BR Pharm ()
Cozachew Fizz Combi ()
Joint-Flex Daily ()
Gosachew ()
Pro Coxam ()
Cosamin ()
Cozachew Meltdown 1500 ()
Cozachew Meltdown Combi ()
Cozachew Fizz ()
Ardern ()
Alateris ()
Fosachew ()
Fosaveg ()
Gosaveg ()
Flexi-melt ()
NSC-758 ()
NSC-234443 ()
Glucosamine HCl Meltdown ()
Glucosamine HCl ()
Bio-Health ()
Glucosamine hydrochloride ()
GLUCOSAMINE SULFATE POTASSIUM CHLORIDE ()
GLUCOSAMINE SULFATE SODIUM CHLORIDE ()
P&D ID
PD009919
CAS
3416-24-8
66-84-2
1078691-95-8
90-77-7
Tags
available
drug
drug candidate
Approved by
FDA
Drug indication
Osteoarthritis
rheumatic disease
osteoarthritis, knee
Drug Status
investigational
approved
Max Phase
4.0
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Glucosamine is a precursor of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use. Glucosamine is not FDA approved for use in humans. Since glucosamine is classified as a dietary supplement, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.
PRICE
29
DESCRIPTION
Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
12
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
123
Molecular Weight
179.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-3.25
TPSA
116.17
Fraction CSP3
1.0
Chiral centers
5.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Autophagy
HIF/HIF Prolyl-Hydroxylase
CFTR
MMP antagonist
NF-¦ÊB inhibitor
TNF inhibitor
Pathway
Metabolic Enzyme/Protease
NF-¦ªb
Chromatin/Epigenetic
Immunology/Inflammation
Metabolism
NF-κB
Membrane Transporter/Ion Channel
Target
NF-¦ÊB
IF¦Ã
TNF-¦Á
GLUT
Endogenous Metabolite
Reactive Oxygen Species
Therapeutic Class
Antiinflammatory Agents
Source data
