General
Preferred name
GLUCOSAMINE
Synonyms
Chitosamine hydrochloride ()
D-(+)-Glucosamine hydrochloride ()
2-Amino-2-deoxy-glucose HCl ()
Chitosamine HCl ()
Chitosamine ()
D-glucosamine ()
GLUCOSAMINE HYDROCHLORIDE ()
2-Amino-2-deoxyglucose (hydrochloride) ()
GLUCOSAMINE SULFATE POTASSIUM CHLORIDE ()
GLUCOSAMINE SULFATE SODIUM CHLORIDE ()
GLUCOSAMINE SULFATE ()
2-Amino-2-deoxy-glucose HCl, Chitosamine HCl ()
Mediflex ()
NSC-234443 ()
D-glucosamine hydrochloride ()
Cozachew Meltdown Combi ()
Alateris ()
Gosaveg ()
Fosachew ()
Joint-Flex Daily ()
Fosaveg ()
Flexi-melt ()
Pro Coxam ()
Glucosamine HCl Meltdown ()
NSC-758 ()
Cozachew Fizz Combi ()
Cozachew Fizz ()
Gosachew ()
Glucosamine (as hydrochloride) ()
Glucosamine HCl ()
BR Pharm ()
Glucosamine hydrochloride ()
Ardern ()
Bio-Health ()
Cosamin ()
Cozachew Meltdown 1500 ()
Glucosamine hydrochloride ()
Faximin ()
Tiocondramina ()
Glusartel ()
Glucosamine sulf ()
Glucosamine sulfate salt ()
Dolenio ()
P&D ID
PD009919
CAS
66-84-2
3416-24-8
1078691-95-8
Tags
drug candidate
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
Drug indication
Osteoarthritis
Max Phase
Phase 2
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Glucosamine is a precursor of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use. Glucosamine is not FDA approved for use in humans. Since glucosamine is classified as a dietary supplement, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.
Compound Sets
12
ChEMBL Approved Drugs
CHEMBL493287
CHEMBL3989750
CHEMBL1707007
ChEMBL Drugs
CHEMBL493287
CHEMBL3989750
CHEMBL1707007
CHEMBL3989618
CHEMBL3989707
DrugBank
DB01296
DrugBank Approved Drugs
DB01296
DrugCentral
1307
DrugCentral Approved Drugs
1307
DrugMAP
DM4ZLFD
DrugMAP Approved Drugs
DM4ZLFD
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-N9459
Selleckchem Bioactive Compound Library
glucosamine-hydrochloride
TargetMol Bioactive Compound Library
T0429
T2941
External IDs
70
Properties
(calculated by RDKit )
Molecular Weight
179.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-3.25
TPSA
116.17
Fraction CSP3
1.0
Chiral centers
5.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Metabolism
Apoptosis
Membrane Transporter/Ion Channel
NF-??b
Proteases/Proteasome
Metabolic Enzyme/Protease
NF-¦ªb
Target
HIF/HIF Prolyl-Hydroxylase
Chitosanase
MMP-9
NF-??B
IF??
TNF-??
NF-¦ÊB
IF¦Ã
TNF-¦Á
MOA
CFTR
MMP antagonist
NF-¦ÊB inhibitor
TNF inhibitor
Therapeutic Class
Antiinflammatory Agents
Source data