General
Preferred name
PRACTOLOL
Synonyms
dl-Practolol ()
Practolol,(+) ()
Practolol,(-) ()
Dalzic ()
ICI-50172 ()
AY-21011 ()
I.C.I.-50,172 ()
[3-(4-Acetylamino-Phenoxy)-2-Hydroxy-Propyl]-Isopropyl-Ammonium ()
I.C.I. 50,172 ()
Eraldin ()
AY-21,011 ()
P&D ID
PD009918
CAS
6673-35-4
Tags
natural product
drug
available
Drug Status
approved
withdrawn
Drug indication
Cardiac arrhythmias
Anti-Adrenergic (beta-receptor)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY
Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.;
DESCRIPTION
The approved drug practolol is mixture of two enantiomers; (R)-practolol and (S)-practolol. The structure shown here does not specify stereochemistry and represents the mixture.
(GtoPdb)
DESCRIPTION
Practolol is a selective beta-1 adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. lt competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. lt inhibits the effects of the catecholamines epinephrine and norepinephrine and decreases heart rate, cardiac output, and systolic and diastolic blood pressure. lt has anti-hyperstensive activity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
23
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
266.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
1.38
TPSA
70.59
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??-adrenoceptor
Adrenergic Receptor
ATC
C07AB01
Toxicity type
dermatological
Therapeutic Class
Antiarrhythmic Agents
Solubility
DMSO: soluble15 mg/mL, clear
Source data
