General
Preferred name
atropine
Synonyms
Atropine (sulfate monohydrate) ()
Atropine sulfate hydrate ()
Atropette ()
Tropintran ()
ATROPINE SULFATE ()
Atropine (sulfate) ()
Tropine tropate (sulfate monohydrate) ()
DL-Hyoscyamine (sulfate monohydrate) ()
Tropine tropate ()
DL-Hyoscyamine ()
Tropine tropate (sulfate) ()
DL-Hyoscyamine (sulfate) ()
Sulfatropinol ()
Sulfatropinol, Atropette, Tropintran ()
Atropine sulfate monohydrate ()
Atropine component of duodote ()
Atropine component of atnaa ()
Atroject ()
ATROPEN ()
ATROPINUM ()
ATROPINE (AUTOINJECTOR) ()
Atrophate ()
Atropine ()
Atropini sulfas ()
Atropine Sulfate Ansyr Plastic Syringe ()
Atropine sulfate component of lomanate ()
Atropine sulfate component of motofen ()
Atropine sulfate component of low-quel ()
Atropine sulfate component of di-atro ()
Atropine sulfate component of lo-trol ()
NSC-755889 ()
Atropine sulfate component of logen ()
NSC-26671 ()
Isopto Atropine ()
Atropt ()
Atropine sulfate component of lonox ()
Atropine sulfate lifeshield abboject syringe ()
SYD-101 ()
Atropine sulfate component of colonaid ()
Atropinum sulphuricum ()
Atropine sulfate component of lomotil ()
Atropisol ()
Atropine sulfate anhydrous ()
Atropine sulfate component of enlon-plus ()
Atropine-d5 ()
ATROPINE COMPONENT OF ATNAA ()
ATROPINE COMPONENT OF DUODOTE ()
P&D ID
PD009911
CAS
5908-99-6
51-55-8
55-48-1
2124269-77-6
Tags
available
drug
natural product
Approved by
FDA
First approval
1960
Drug Status
vet_approved
approved
Max Phase
4.0
Drug indication
Seasonal allergic rhinitis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Atropine is a muscarinic acetylcholine receptor (mAChR) antagonist. (GtoPdb)
DESCRIPTION Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
DESCRIPTION Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia[1][2][3][4].
Cell lines
0
Organisms
3
Compound Sets
20
Cayman Chemical Bioactives
12008
32997
30734
ChEMBL Approved Drugs
CHEMBL517712
CHEMBL2146146
ChEMBL Drugs
CHEMBL517712
CHEMBL2146146
Concise Guide to Pharmacology 2017/18
320
Concise Guide to Pharmacology 2019/20
320
Concise Guide to Pharmacology 2021/22
320
Concise Guide to Pharmacology 2023/24
320
DrugBank
DB00572
DrugBank Approved Drugs
DB00572
DrugCentral
260
DrugCentral Approved Drugs
260
EUbOPEN Chemogenomics Library
EUB0000905
Guide to Pharmacology
320
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL517712
MedChem Express Bioactive Compound Library
HY-B1205
HY-B1205A
HY-B0394
NCATS Inxight Approved Drugs
7C0697DR9I
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Atropine-sulfate-monohydrate
atropine
atropine-sulfate
External IDs
82
Properties
(calculated by RDKit )
Molecular Weight
289.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
1.93
TPSA
49.77
Fraction CSP3
0.59
Chiral centers
4.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
Autophagy
Endogenous Metabolite
AChR,ADC Cytotoxin
AChR
Pathway
Neuronal Signaling
GPCR/G protein
Neuroscience
Metabolic Enzyme/Protease
MOA
AChR antagonist
Recommended Cell Concentration
10 nM
Source data