General
Preferred name
CLONIDINE
Synonyms
CLONIDINE HYDROCHLORIDE ()
Clonidine HCl ()
Catapres ()
Nexiclon ()
Kapvay ()
Clonidine (hydrochloride) ()
Ipotensium ()
Clonidine (hydrochloride) ()
NSC-756699 ()
ST-155 ()
CATAPRES TTS 1 ()
CATAPRES TTS 2 ()
DIXARIT ()
DURACLON ()
CATAPRES TTS 3 ()
DICHLORANILINO IMIDAZOLIN ()
Onyda xr ()
JENLOGA ()
Clonidine hydrochloride component of combipres ()
CATAPRES P.L. ()
Clonidine hydrochloride component of clorpres ()
ST-155BS ()
Clonidina ()
Clonidine extended release ()
Nexiclon xr ()
Catapres-Tts-2 ()
Clorpres ()
Catapres-Tts-1 ()
Catapres-Tts-3 ()
ST-155-BS ()
Catarpres-tts ()
Combipres ()
Clonidine-d4 (hydrochloride) ()
CLONIDINE HYDROCHLORIDE COMPONENT OF CLORPRES ()
CLONIDINE HYDROCHLORIDE COMPONENT OF COMBIPRES ()
ONYDA XR ()
P&D ID
PD009910
CAS
4205-91-8
4205-90-7
67151-02-4
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
1974
Drug indication
Hypertension
Attention deficit hyperactivity disorder
Diabetic neuropathy
Pain
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clonidine hydrochloride is an agonist of ¦Á2-adrenoceptor and potent antihypertensive agent.
PRICE 29
DESCRIPTION Clonidine hydrochloride (Catapres) is a centrally active ??-adrenergic agonist used predominantly as an antihypertensive agent.
DESCRIPTION Clonidine is an α2 adrenoceptor agonist.
The structure shown here is in the amino form. A tautomeric imino form, represented by CHEBI:3757 also exists. (GtoPdb)
DESCRIPTION Clonidine is an alpha 2-adrenergic agonist[1].
PRICE 29
DESCRIPTION Muscarinic agonist (Tocris Bioactive Compound Library)
DESCRIPTION alpha2 Adrenoceptor agonist; antihypertensive (LOPAC library)
DESCRIPTION α2 agonist. Also I1 ligand (Tocriscreen Total)
DESCRIPTION Clonidine hydrochloride is an agonist of alpha-2-adrenoceptor and potent antihypertensive agent. It is used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. (Enamine Bioactive Compounds)
DESCRIPTION Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent. (TargetMol Bioactive Compound Library)
DESCRIPTION Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent, usually in combination with other agents. Despite wide-scale use for many years, clonidine has not been linked definitively to either serum aminotransferase elevations or clinically apparent liver injury. (TargetMol Bioactive Compound Library)
Compound Sets
39
AdooQ Bioactive Compound Library
A10232
Axon Medchem Screening Library
3044
BiasDB
Clonidine
Cayman Chemical Bioactives
15949
38558
28519
ChEMBL Approved Drugs
CHEMBL1705
CHEMBL134
ChEMBL Drugs
CHEMBL1705
CHEMBL134
Concise Guide to Pharmacology 2017/18
516
Concise Guide to Pharmacology 2019/20
516
Concise Guide to Pharmacology 2021/22
516
Concise Guide to Pharmacology 2023/24
516
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00575
DrugBank Approved Drugs
DB00575
DrugCentral
704
DrugCentral Approved Drugs
704
DrugMAP
DM6RZ9Q
DrugMAP Approved Drugs
DM6RZ9Q
DrugMatrix
Enamine Bioactive Compounds
EBC-08213
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101811
EUbOPEN Chemogenomics Library
EUB0000904
Guide to Pharmacology
13162
516
Ki Database
CLONIDINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1705
CHEMBL134
MedChem Express Bioactive Compound Library
HY-B0409A
HY-12721
NCATS Inxight Approved Drugs
MN3L5RMN02
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Clonidine-hydrochloride(Catapres)
TargetMol Bioactive Compound Library
T1247
T7045
The Spectrum Collection
Tocris Bioactive Compound Library
0690
Tocriscreen Total
External IDs
79
Properties
(calculated by RDKit )
Molecular Weight
229.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
2.36
TPSA
36.42
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha2
Target
Adrenergic Receptor
α2 adrenergic receptor
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C
a2 agonist
Adrenergic Receptor,Autophagy
Primary Target
Adrenergic ?2 Receptors
MOA
Agonist
alpha2-Adrenoceptor Agonists
ADRA1B gene stimulator
Adrenergic Receptor agonist
Member status
virtual
Disease Area
cardiology, neurology/psychiatry
Indication
hypertension, attention-deficit/hyperactivity disorder (ADHD)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antihypertensive Agents
Recommended Cell Concentration
None
Source data