General
Preferred name
MAZINDOL
Synonyms
Mazindol ()
SAH-42548 ()
Mazanor ()
Terenac ()
Teronac ()
42-548 ()
Magrilon ()
Mazildene ()
Mazindol civ ()
Sanorex ()
AN-448 ()
Mazindol-d4 ()
P&D ID
PD009907
CAS
22232-71-9
1246815-50-8
Tags
available
drug
Approved by
FDA
First approval
1973
Drug Status
investigational
approved
withdrawn
Drug indication
Obesity
Anorexic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mazindol is a tetracyclic chemical, with anorectic, appetite suppressing action. Pharmacologically it acts as a sympathomimetic amine (like ). (GtoPdb)
TOXICITY Symptoms of mazindol overdose may be associated with restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.
MOA Unlike other sympathomimetic appetite suppressants such as phentermine, mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release.
PHARMACODYNAMICS Mazindol is a sympathomimetic amine that stimulates the central nervous system (nerves and brain), leading to increased your heart rate and blood pressure, and decreased appetite. Since the appetite-suppressing effect of the drug tends to decrease after few weeks of treatment, sympathomimetic appetite suppressants are typically used short-term weight-loss program.
Cell lines
1
Organisms
0
Compound Sets
19
Cayman Chemical Bioactives
21642
21640
ChEMBL Approved Drugs
CHEMBL781
ChEMBL Drugs
CHEMBL781
Concise Guide to Pharmacology 2017/18
4591
4797
Concise Guide to Pharmacology 2019/20
4591
4797
Concise Guide to Pharmacology 2021/22
4591
4797
Concise Guide to Pharmacology 2023/24
4591
4797
DrugBank
DB00579
DrugBank Approved Drugs
DB00579
DrugCentral
1640
DrugCentral Approved Drugs
1640
DrugMAP
DMZ36RN
DrugMAP Approved Drugs
DMZ36RN
DrugMatrix
Guide to Pharmacology
4591
4797
Ki Database
MAZINDOL
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL781
ReFrame library
Withdrawn 2.0
409
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
284.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
2.61
TPSA
35.83
Fraction CSP3
0.19
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
A08AA05
Therapeutic Class
Central Nervous System Stimulants
Source data