General
Preferred name
DICLOFENAC
Synonyms
DICLOFENAC SODIUM ()
Diclofenac sodium salt ()
Diclofenacum ()
Voltaren ()
GP 45840 ()
CGP-45840B ()
Cataflam ()
Voltfast ()
Diclofenac hydroxyethylpyrrolidine ()
DHEP ()
DIEP ()
"Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, monosodium salt" ()
DICLOFENAC EPOLAMINE ()
Diclofenac (diethylamine) ()
Diclofenac (Sodium) ()
Diclofenac (potassium) ()
DHEP, DIEP, diclofenac hydroxyethylpyrrolidine ()
{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid ()
Diclofenac Diethylamine ()
DICLOFENAC POTASSIUM ()
Diclofenac acid ()
Diclofenac (sodium salt) ()
Diclofenac-d4 ()
Voltarol ()
Fenactol ()
Enstar XL ()
Novapirina ()
Effekton ()
Rewodina ()
Voltarol SR ()
Pennsaid ()
Lofensaid 50 ()
Acoflam ()
Dicloreum ()
Solaraze ()
Rhumalgan SR ()
Benfofen ()
Mobigel Paineze ()
Diclofenac sodium component of arthrotec ()
Volsaid Ret 100 ()
Diclotard 100 MR ()
Defanac ()
Diclovol Ret ()
Fenactol Ret ()
Valdic 75 Ret ()
Diclophlogont ()
Acoflam SR ()
Arthronac ()
GP-45840 ()
Enzed ()
Voltarol Gel Patch ()
Lofensaid Ret 100 ()
Dicloflex SR ()
Dicloflex ()
Dyloject ()
Rheumatac Ret 75 ()
Dexomon SR ()
Diclovol ()
Diclomax SR ()
Voltarene ()
Voltarene Ret ()
Motifene ()
Voltarol Emulgel ()
Delphinac ()
Lofensaid Ret 75 ()
Defanac SR ()
Rhumalgan CR 75 ()
Enstar SR ()
Mobigel ()
Voltarol Ret ()
Sodium diclofenac ()
Voltarene L.P. ()
Dealgic ()
Diclozip 50 ()
Voltarol Ophtha ()
Xenid ()
Volsaid Ret 75 ()
Difenor XL ()
Voltarol 12 Hour Emulgel P ()
Digenac XL 100 ()
Voldal ()
Voltarol Pain-eze Emulgel ()
Valenac ()
Prophenatin ()
Flamatak MR ()
Isclofen ()
Diclomax ()
Duravolten ()
Masidemen ()
Rhumalgan XL ()
Closteril 100 ()
Voltarol Active ()
Voltaren-XR ()
Rhumalgan CR 100 ()
Arthrotec 75 ()
Diclotard 75 MR ()
Econac SR ()
Abitren ()
Diclophenac sodium ()
Diclofenac diethylammonium salt ()
Acoflam Ret ()
Rhumalgan ()
Dicloflex Ret ()
Voltarene Emulgel ()
Flamrase ()
Slofenac ()
Flexotard MR ()
Lexobene ()
Voltaren arthritis pain ()
Flamrase SR ()
Neriodin ()
Voltaren Ret ()
Dexomon Ret ()
Diclofenac sod ()
Voltarol Emulgel P ()
Fenactol SR ()
Defanac Retard ()
Volraman ()
Diclofenac diethylammonium ()
Econac ()
Lofensaid 25 ()
Misofen ()
Diclofenac diethylamine salt ()
NSC-756725 ()
Deflamat ()
Diclovol SR ()
Ecofenac ()
Primofenac ()
Econac XL ()
Arthrotec 50 ()
Voltaren Emulgel ()
Diclomax Ret ()
Diclozip 25 ()
Valdic 100 Ret ()
LAS41007 ()
Voltaren Ophthalmic ()
DICLOFENAC FREE ACID ()
Arthrotec ()
Zorvolex Capsules ()
LAS-41007 ()
Voltaren XR ()
ZORVOLEX ()
DICLOFENACO ()
Potassium diclofenac ()
Voltarol Joint Pain ()
Voltarol Rapid ()
Diclofenac potassium salt ()
Voltarol Pain-eze Extra Strgh ()
Zipsor ()
Cambia ()
Voltarol Pain-eze ()
CGP 45840B ()
Flector Patch ()
Flector ()
Diclofenac epolaminum ()
Licart ()
P&D ID
PD009905
CAS
15307-79-6
15307-86-5
153466-65-0
78213-16-8
15307-81-0
119623-66-4
128402-48-2
Tags
available
drug
Approved by
PMDA
FDA
First approval
1988
1993
2007
Drug indication
Actinic keratosis
Pain
Eye inflammation
Osteoarthritis
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 ¦ÌM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
PRICE 29
DESCRIPTION Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) (GtoPdb)
DESCRIPTION Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 ¦ÌM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
PRICE 29
PRICE 29
DESCRIPTION Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 ¦ÌM for ovine COX-1 and COX-2, respectively[2]. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
DESCRIPTION Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 ¦ÌM for ovine COX-1 and COX-2, respectively[2]. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
PRICE 29
DESCRIPTION Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID)[1]. Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies[2].
PRICE 36
DESCRIPTION Potent and selective PLK2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Cyclooxygenase inhibitor; anti-inflammatory (LOPAC library)
DESCRIPTION Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. (TargetMol Bioactive Compound Library)
DESCRIPTION Diclofenac is a potent and nonselective anti-inflammatory agent (NSAID) , acts as a COX inhibitor. Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and akylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. (Enamine Bioactive Compounds)
DESCRIPTION Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. (TargetMol Bioactive Compound Library)
DESCRIPTION Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). (TargetMol Bioactive Compound Library)
DESCRIPTION Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. (TargetMol Bioactive Compound Library)
DESCRIPTION Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
2
Compound Sets
38
AdooQ Bioactive Compound Library
A10304
Cayman Chemical Bioactives
70680
19072
22983
ChEMBL Approved Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
ChEMBL Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
Concise Guide to Pharmacology 2017/18
2714
Concise Guide to Pharmacology 2019/20
2714
Concise Guide to Pharmacology 2021/22
2714
Concise Guide to Pharmacology 2023/24
2714
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00586
DrugBank Approved Drugs
DB00586
DrugCentral
865
DrugCentral Approved Drugs
865
DrugMAP
DMPIHLS
DrugMAP Approved Drugs
DMPIHLS
DrugMatrix
Enamine Bioactive Compounds
EBC-03832
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100332
EUbOPEN Chemogenomics Library
EUB0000761
Guide to Pharmacology
2714
IPPI - DB
1993
Ki Database
Diclofenac sodium salt
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1034
CHEMBL139
MedChem Express Bioactive Compound Library
HY-15037
HY-15036
HY-15036A
HY-15038
HY-109547
NCATS Inxight Approved Drugs
144O8QL0L1
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Diclofenac-sodium
diclofenac-acid
diclofenac-diethylamine
diclofenac-potassium
diclofenac-epolamine
TargetMol Bioactive Compound Library
T1555
T0196
T0432
T6470
T22307
The Spectrum Collection
Tocris Bioactive Compound Library
4454
External IDs
158
Properties
(calculated by RDKit )
Molecular Weight
295.02
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.36
TPSA
49.33
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Target
Apoptosis
COX-1
COX-2
AKR1C3, ALOX5, ASIC1, ASIC3, KCNQ2, KCNQ3, PLA2G2A, PPARG, PTGS1, PTGS2, SCN4A
Immunology & Inflammation related
COX,Immunology & Inflammation related
Primary Target
Cyclooxygenases
MOA
COX inhibitor
Inhibitor
Cyclooxygenase-3 Inhibitors
Cyclooxygenase-1 Inhibitors
Cyclooxygenase-2 Inhibitors
Non-Steroidal Antiinflammatory Drugs
Voltage-Gated K(V) 7.2 (KCNQ2) Channel Activators
cyclooxygenase inhibitor
Member status
virtual
Indication
rheumatoid arthritis, osteoarthritis, migraine headache
Disease Area
rheumatology, neurology/psychiatry
Therapeutic Class
Neurology Agents
Pathway
Immunology/Inflammation
Neuroscience
Recommended Cell Concentration
None
Source data