General
Preferred name
DICLOFENAC
Synonyms
DICLOFENAC SODIUM ()
GP 45840 ()
Diclofenacum ()
Voltaren ()
Diclofenac sodium salt ()
Diclofenac Diethylamine ()
Diclofenac (diethylamine) ()
Diclofenac (Sodium) ()
Diclofenac (potassium) ()
"Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, monosodium salt" ()
DICLOFENAC POTASSIUM ()
DICLOFENAC EPOLAMINE ()
Diclofenac acid ()
CGP-45840B ()
DHEP, DIEP, diclofenac hydroxyethylpyrrolidine ()
Acoflam Ret ()
Neriodin ()
Lofensaid Ret 75 ()
Flexotard MR ()
Dicloflex ()
Diclovol Ret ()
Rheumatac Ret 75 ()
Masidemen ()
Diclomax Ret ()
Econac XL ()
Voltaren arthritis pain ()
Econac SR ()
Lofensaid 25 ()
Voltarol SR ()
Econac ()
Arthrotec 75 ()
Isclofen ()
Dicloflex Ret ()
Valdic 100 Ret ()
Dexomon SR ()
Valdic 75 Ret ()
Diclotard 75 MR ()
Arthrotec 50 ()
Acoflam ()
Xenid ()
Enzed ()
Defanac Retard ()
Pennsaid ()
Effekton ()
Dicloflex SR ()
Diclotard 100 MR ()
Rhumalgan XL ()
Flamrase SR ()
Acoflam SR ()
Sodium diclofenac ()
Rhumalgan ()
Enstar SR ()
Rhumalgan CR 75 ()
Lexobene ()
Voltarol ()
GP-45840 ()
Voltarol Active ()
Arthronac ()
Voltarol Gel Patch ()
Voltarene Emulgel ()
Voltarene L.P. ()
Voltaren-XR ()
Prophenatin ()
NSC-756725 ()
Ecofenac ()
Delphinac ()
Slofenac ()
Valenac ()
Solaraze ()
Benfofen ()
Voltaren Emulgel ()
Rhumalgan SR ()
Motifene ()
Difenor XL ()
Misofen ()
Diclozip 25 ()
Fenactol Ret ()
Voltarene Ret ()
Diclofenac diethylammonium salt ()
Fenactol ()
Closteril 100 ()
Novapirina ()
Mobigel Paineze ()
Defanac SR ()
Flamrase ()
Voltaren Ret ()
Diclofenac diethylamine salt ()
Lofensaid Ret 100 ()
Voltarol Ophtha ()
Defanac ()
Flamatak MR ()
Volsaid Ret 100 ()
Diclophenac sodium ()
Enstar XL ()
Diclomax SR ()
Diclomax ()
Rhumalgan CR 100 ()
Lofensaid 50 ()
Dealgic ()
Duravolten ()
Deflamat ()
Voldal ()
Diclophlogont ()
Volraman ()
Diclovol ()
Dyloject ()
Diclovol SR ()
Dicloreum ()
Digenac XL 100 ()
Diclozip 50 ()
Rewodina ()
Volsaid Ret 75 ()
Voltarol 12 Hour Emulgel P ()
Mobigel ()
Diclofenac sod ()
Voltarol Pain-eze Emulgel ()
Dexomon Ret ()
Primofenac ()
Voltarene ()
Fenactol SR ()
Voltarol Emulgel ()
Voltarol Emulgel P ()
Voltarol Ret ()
Diclofenac diethylammonium ()
Abitren ()
LAS41007 ()
Cambia ()
Zorvolex Capsules ()
Voltaren Xr ()
Cataflam ()
Zorvolex ()
Voltaren Ophthalmic ()
Arthrotec ()
Diclofenac free acid ()
LAS-41007 ()
Voltarol Joint Pain ()
Voltarol Pain-eze Extra Strgh ()
Zipsor ()
Potassium diclofenac ()
Voltarol Pain-eze ()
CGP 45840B ()
Voltarol Rapid ()
Diclofenac potassium salt ()
Flector ()
Flector Patch ()
Licart ()
Diclofenac epolaminum ()
Diclofenac (sodium salt) ()
Diclofenac-d4 ()
P&D ID
PD009905
CAS
15307-79-6
78213-16-8
15307-86-5
153466-65-0
15307-81-0
119623-66-4
128402-48-2
Tags
natural product
drug
available
Approved by
PMDA
FDA
First approval
1993
1988
2007
Drug Status
approved
vet_approved
Drug indication
Osteoarthritis
Anti-Inflammatory
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) (GtoPdb)
DESCRIPTION Potent and selective PLK2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Cyclooxygenase inhibitor; anti-inflammatory (LOPAC library)
Cell lines
3
Organisms
2
Compound Sets
35
AdooQ Bioactive Compound Library
A10304
Cayman Chemical Bioactives
70680
19072
22983
ChEMBL Approved Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
ChEMBL Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
Concise Guide to Pharmacology 2017/18
2714
Concise Guide to Pharmacology 2019/20
2714
Concise Guide to Pharmacology 2021/22
2714
Concise Guide to Pharmacology 2023/24
2714
Drug Repurposing Hub
DrugBank
DB00586
DrugBank Approved Drugs
DB00586
DrugCentral
865
DrugCentral Approved Drugs
865
DrugMAP
DMPIHLS
DrugMAP Approved Drugs
DMPIHLS
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100332
Guide to Pharmacology
2714
IPPI - DB
1993
Ki Database
Diclofenac sodium salt
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1034
CHEMBL139
MedChem Express Bioactive Compound Library
HY-15037
HY-15036
HY-15036A
HY-15038
NCATS Inxight Approved Drugs
144O8QL0L1
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Diclofenac-sodium
diclofenac-acid
diclofenac-diethylamine
diclofenac-potassium
diclofenac-epolamine
TargetMol Bioactive Compound Library
T1555
T0196
T0432
The Spectrum Collection
Tocris Bioactive Compound Library
4454
External IDs
147
Properties
(calculated by RDKit )
Molecular Weight
295.02
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.36
TPSA
49.33
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Pathway
Immunology/Inflammation
Neuroscience
Apoptosis
Target
COX-1
COX-2
huMan COX-2(in CHO cells)
human COX-1(in CHO cells)
ovine COX-2
ovine COX-1
AKR1C3, ALOX5, ASIC1, ASIC3, KCNQ2, KCNQ3, PLA2G2A, PPARG, PTGS1, PTGS2, SCN4A
Immunology & Inflammation related
COX,Immunology & Inflammation related
Primary Target
Cyclooxygenases
MOA
COX inhibitor
Inhibitor
Cyclooxygenase-3 Inhibitors
Cyclooxygenase-1 Inhibitors
Cyclooxygenase-2 Inhibitors
Non-Steroidal Antiinflammatory Drugs
Voltage-Gated K(V) 7.2 (KCNQ2) Channel Activators
cyclooxygenase inhibitor
Member status
virtual
Indication
rheumatoid arthritis, osteoarthritis, migraine headache
Disease Area
rheumatology, neurology/psychiatry
Therapeutic Class
Neurology Agents
Source data