General
Preferred name
DICLOFENAC
Synonyms
DICLOFENAC SODIUM ()
Diclofenac hydroxyethylpyrrolidine ()
GP 45840 ()
Diclofenacum ()
Voltaren ()
Diclofenac sodium salt ()
Diclofenac Diethylamine ()
DICLOFENAC EPOLAMINE ()
Diclofenac (diethylamine) ()
Diclofenac (Sodium) ()
Diclofenac (potassium) ()
"Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, monosodium salt" ()
{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid ()
DICLOFENAC POTASSIUM ()
Diclofenac acid ()
CGP-45840B ()
DHEP, DIEP, diclofenac hydroxyethylpyrrolidine ()
Arthrotec 75 ()
Solaraze ()
Enstar SR ()
Diclophenac sodium ()
Diclofenac diethylamine salt ()
Neriodin ()
Voldal ()
Voltarene Ret ()
Defanac ()
Voltarene ()
Masidemen ()
Ecofenac ()
Valdic 75 Ret ()
Effekton ()
Misofen ()
Fenactol SR ()
Lofensaid 25 ()
Diclofenac diethylammonium salt ()
Flamatak MR ()
Voltarol Ret ()
Acoflam Ret ()
Voltarol Ophtha ()
Difenor XL ()
Diclomax SR ()
Delphinac ()
Voltarol Active ()
Voltaren Emulgel ()
Diclotard 100 MR ()
Rhumalgan CR 75 ()
Acoflam SR ()
Diclophlogont ()
NSC-756725 ()
Diclovol ()
Xenid ()
Dealgic ()
Diclomax Ret ()
Sodium diclofenac ()
Diclofenac diethylammonium ()
Fenactol ()
Flexotard MR ()
Mobigel ()
Volsaid Ret 100 ()
Rhumalgan XL ()
Rewodina ()
Arthronac ()
Lofensaid Ret 75 ()
Defanac Retard ()
Fenactol Ret ()
Dyloject ()
Diclomax ()
Slofenac ()
Diclozip 50 ()
Rheumatac Ret 75 ()
Dexomon Ret ()
Voltarol Pain-eze Emulgel ()
Volraman ()
Flamrase SR ()
Defanac SR ()
Volsaid Ret 75 ()
Diclovol SR ()
Econac XL ()
Diclovol Ret ()
Econac SR ()
Valdic 100 Ret ()
Voltarene L.P. ()
Deflamat ()
Voltaren arthritis pain ()
Dicloflex Ret ()
Diclotard 75 MR ()
Isclofen ()
Rhumalgan CR 100 ()
Prophenatin ()
Lexobene ()
Voltarol 12 Hour Emulgel P ()
Flamrase ()
Abitren ()
Lofensaid 50 ()
Voltarol Gel Patch ()
Econac ()
Diclozip 25 ()
Voltarol Emulgel P ()
Lofensaid Ret 100 ()
GP-45840 ()
Pennsaid ()
Mobigel Paineze ()
Voltarol Emulgel ()
Enstar XL ()
Duravolten ()
Benfofen ()
Voltaren-XR ()
Diclofenac sod ()
Dicloflex ()
Dexomon SR ()
Dicloreum ()
Digenac XL 100 ()
Rhumalgan SR ()
Enzed ()
Novapirina ()
Voltarol SR ()
Primofenac ()
Voltarol ()
Rhumalgan ()
Valenac ()
Closteril 100 ()
Acoflam ()
Voltaren Ret ()
Arthrotec 50 ()
Dicloflex SR ()
Motifene ()
Voltarene Emulgel ()
LAS41007 ()
Cambia ()
Voltaren Ophthalmic ()
Arthrotec ()
LAS-41007 ()
DICLOFENAC FREE ACID ()
Voltaren XR ()
Zorvolex Capsules ()
Diclofenaco ()
ZORVOLEX ()
Cataflam ()
Zipsor ()
Voltarol Rapid ()
CGP 45840B ()
Potassium diclofenac ()
Diclofenac potassium salt ()
Voltarol Pain-eze Extra Strgh ()
Voltarol Pain-eze ()
Voltarol Joint Pain ()
Flector ()
Licart ()
Flector Patch ()
Diclofenac epolaminum ()
Diclofenac (sodium salt) ()
Diclofenac-d4 ()
DICLOFENACO ()
P&D ID
PD009905
CAS
15307-79-6
78213-16-8
15307-86-5
153466-65-0
15307-81-0
119623-66-4
128402-48-2
Tags
available
drug
Approved by
FDA
PMDA
First approval
1993
1988
2007
Drug indication
Osteoarthritis
Anti-Inflammatory
Drug Status
approved
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) (GtoPdb)
DESCRIPTION Potent and selective PLK2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Cyclooxygenase inhibitor; anti-inflammatory (LOPAC library)
Cell lines
3
Organisms
2
Compound Sets
37
AdooQ Bioactive Compound Library
A10304
Cayman Chemical Bioactives
70680
19072
22983
ChEMBL Approved Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
ChEMBL Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
Concise Guide to Pharmacology 2017/18
2714
Concise Guide to Pharmacology 2019/20
2714
Concise Guide to Pharmacology 2021/22
2714
Concise Guide to Pharmacology 2023/24
2714
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00586
DrugBank Approved Drugs
DB00586
DrugCentral
865
DrugCentral Approved Drugs
865
DrugMAP
DMPIHLS
DrugMAP Approved Drugs
DMPIHLS
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100332
EUbOPEN Chemogenomics Library
EUB0000761
Guide to Pharmacology
2714
IPPI - DB
1993
Ki Database
Diclofenac sodium salt
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1034
CHEMBL139
MedChem Express Bioactive Compound Library
HY-15037
HY-15036
HY-15036A
HY-15038
HY-109547
NCATS Inxight Approved Drugs
144O8QL0L1
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Diclofenac-sodium
diclofenac-acid
diclofenac-diethylamine
diclofenac-potassium
diclofenac-epolamine
TargetMol Bioactive Compound Library
T1555
T0196
T0432
The Spectrum Collection
Tocris Bioactive Compound Library
4454
External IDs
157
Properties
(calculated by RDKit )
Molecular Weight
295.02
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.36
TPSA
49.33
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Pathway
Immunology/Inflammation
Neuroscience
Apoptosis
Target
COX-1
COX-2
huMan COX-2(in CHO cells)
human COX-1(in CHO cells)
ovine COX-2
ovine COX-1
AKR1C3, ALOX5, ASIC1, ASIC3, KCNQ2, KCNQ3, PLA2G2A, PPARG, PTGS1, PTGS2, SCN4A
Immunology & Inflammation related
COX,Immunology & Inflammation related
Primary Target
Cyclooxygenases
MOA
COX inhibitor
Inhibitor
Cyclooxygenase-3 Inhibitors
Cyclooxygenase-1 Inhibitors
Cyclooxygenase-2 Inhibitors
Non-Steroidal Antiinflammatory Drugs
Voltage-Gated K(V) 7.2 (KCNQ2) Channel Activators
cyclooxygenase inhibitor
Member status
virtual
Indication
rheumatoid arthritis, osteoarthritis, migraine headache
Disease Area
rheumatology, neurology/psychiatry
Therapeutic Class
Neurology Agents
Recommended Cell Concentration
None
Source data