General
Preferred name
LISURIDE
Synonyms
Lisuride maleate ()
Dopergin ()
Lisuride (maleate) ()
lisuride hydrogen maleate, Sinoxa ()
Lysuride maleate ()
Revanil 200 ()
Lysuride ()
P&D ID
PD009903
CAS
19875-60-6
18016-80-3
Tags
available
drug
natural product
biased GPCR ligand
Drug Status
investigational
approved
Drug indication
Fibrosis
Parkinson disease
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Lisuride is an antiparkinson agent of the iso-ergoline class, acting principally as a dopamine receptor partial agonist.
(GtoPdb)
MOA
Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor.
PHARMACODYNAMICS
There is evidence that lisuride lowers prolactin levels and, in low doses, prevents migraine attacks.
DESCRIPTION
Potent, selective MC1 receptor agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antiparkinsonian studies.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
19
BiasDB
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
338.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
2.84
TPSA
51.37
Fraction CSP3
0.45
Chiral centers
2.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Non-selective Dopamine
MOA
Agonist
Dopamine Receptor agonist
Indication
Parkinson's Disease
Target
ADRA1A, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR6
Dopamine Receptor
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antihyperprolactinemia
Therapeutic Class
CNS & PNS
Antiparkinson Agents
Pathway
GPCR/G protein
Neuronal Signaling
Source data
