General
Preferred name
AMILORIDE
Synonyms
AMILORIDE HYDROCHLORIDE ()
Midamor ()
Amiloride hydrochloride dihydrate ()
Amiloride HCl 2H2O ()
Amiloride HCl 2H2O ()
Amiloride (hydrochloride) ()
MK-870 ()
MK-870 hydrochloride ()
MK-870 hydrochloride dihydrate ()
MK-870 HCl ()
Amiloride HCl ()
Amiloride (MK-870) HCl ()
Amiloride HCl dihydrate ()
Amiloride (hydrochloride) (hydrate) ()
Anhydrous amiloride hydrochloride ()
Amipramidine ()
Amoride ()
Amiloridi hydrochloridum ()
Amilamont ()
Amiloride hydrochloride anhydrous ()
Amiloride hydrochloride component of moduretic ()
Berkamil ()
Amilospare 5 ()
Amiloride hydrochloride component of hydro-ride ()
Amiloride hydrochloride dehydrate ()
NSC-755847 ()
Hydro-Ride ()
Amilorida ()
Amiclaran ()
Amiloride hydrochloride hydrate ()
P&D ID
PD009902
CAS
17440-83-4
2609-46-3
2016-88-8
Tags
available
drug
Approved by
FDA
First approval
1981
Drug indication
Congestive heart failure
Hypertension
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
PRICE 29
DESCRIPTION Amiloride hydrochloride (Amiloride HCl) is an effective sodium channel blocker of epithelial.
DESCRIPTION Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
DESCRIPTION Amiloride is a loop diuretic drug. (GtoPdb)
DESCRIPTION Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
DESCRIPTION NMDA antagonist; acts at glycine site (Tocris Bioactive Compound Library)
DESCRIPTION Epithelial Na+ channel blocker (LOPAC library)
DESCRIPTION Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel, used in the management of hypertension and congestive heart failure. (BOC Sciences Bioactive Compounds)
DESCRIPTION Na+ channel blocker. Also I2 imidazoline ligand (Tocriscreen Total)
DESCRIPTION Amiloride is a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. It is indicated for use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension. (Enamine Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
37
AdooQ Bioactive Compound Library
A10064
A11728
BOC Sciences Bioactive Compounds
amiloride-hcl-cas-2016-88-8-333112
Cayman Chemical Bioactives
14409
26295
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1398126
CHEMBL945
ChEMBL Drugs
CHEMBL1398126
CHEMBL945
Concise Guide to Pharmacology 2017/18
2421
Concise Guide to Pharmacology 2019/20
2421
Concise Guide to Pharmacology 2021/22
2421
Concise Guide to Pharmacology 2023/24
2421
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00594
DrugBank Approved Drugs
DB00594
DrugCentral
158
DrugCentral Approved Drugs
158
DrugMAP
DMRTSGP
DrugMAP Approved Drugs
DMRTSGP
DrugMatrix
Enamine Bioactive Compounds
EBC-11033
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100915
Guide to Pharmacology
2421
JUMP-Target 1 Compound Set
16231
Ki Database
Amiloride
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1398126
CHEMBL945
MedChem Express Bioactive Compound Library
HY-B0285A
HY-B0285B
HY-B0285
NCATS Inxight Approved Drugs
7DZO8EB0Z3
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Amiloride-hydrochloride(Midamor)
amilorida
The Spectrum Collection
Tocris Bioactive Compound Library
0890
Tocriscreen Total
External IDs
93
Properties
(calculated by RDKit )
Molecular Weight
229.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.08
TPSA
156.79
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Epithelial
MOA
amiloride-sensitive sodium channel inhibitor
Serine Protease inhibitor
Blocker
Sodium Channel blocker
Target
Amiloride-sensitive sodium channel, ENaC
AOC1, ASIC1, ASIC2, ASIC3, PKD2, PKD2L1, PLAU, SCNN1A, SCNN1B, SCNN1D, SCNN1G, SLC9A1, TRPC7, TRPV2
ASIC1
Apoptosis
Sodium Channel
TRP Channel
Calcium Channel,Serine Protease,Sodium Channel
Primary Target
Voltage-gated Sodium (NaV) Channels
Indication
hypertension, congestive heart failure
Therapeutic Class
Diuretics
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Solubility
Well in water and ethanol
Source data