General
Preferred name
LABETALOL
Synonyms
DILEVALOL ()
LABETALOL HYDROCHLORIDE ()
Sch-15719W ()
AH-5158 hydrochloride ()
Labetalol HCl ()
Labetalol (hydrochloride) ()
AH5158 ()
Sch-15719W (free base) ()
AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W ()
NSC-290312 ()
Labetalol Hydrocloride ()
Ibidomide hydrochloride ()
Labetalol hydrochloride component of normozide ()
Labetalol hydrochloride in sodium chloride ()
Labetalol hydrochloride in dextrose ()
Labrocol ()
Normodyne ()
AH-5158A ()
SCH 15719W ()
Trandate ()
AH-5158A HYDROCHLORIDE ()
SCH-15719W HYDROCHLORIDE ()
AH 5158A ()
Normozide ()
AH-5158A FREE BASE ()
Ibidomide ()
SCH-15719W FREE BASE ()
Labetalol-d5 (hydrochloride) ()
P&D ID
PD009899
CAS
32780-64-6
36894-69-6
32780-40-8
2713514-78-2
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Hypertension
preeclampsia
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Labetalol (AH5158) hydrochloride is an orally available, selective ¦Á1-adrenergic recepto and non-selective ¦Â-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy[1][2][3].
DESCRIPTION Labetalol hydrochloride (Sch-15719W), a salicylamide derivative, is a non-cardioselective blocker of ??-adrenergic receptors and ??1-adrenergic receptors.
DESCRIPTION Marketed formulations may contain labetalol hydrochloride (PubChem CID 71412). (GtoPdb)
DESCRIPTION Labetalol (AH5158) is an orally available, selective ¦Á1-adrenergic recepto and non-selective ¦Â-adrenergic receptor competitive antagonist. Labetalol is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol can be used in the study of cardiovascular diseases, such as hypertension during pregnancy[1][2][3].
PRICE 29
DESCRIPTION Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situations. The pharmacokinetics of labetalol is affected by the common CYP2C19 polymorphisms.
DESCRIPTION Competitive beta-adrenoceptor antagonist (LOPAC library)
DESCRIPTION Labetalol is an alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. (Enamine Bioactive Compounds)
DESCRIPTION Labetalol hydrochloride (Sch-15719W), a salicylamide derivative, is a non-cardioselective blocker of β-adrenergic receptors and α1-adrenergic receptors. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
29
AdooQ Bioactive Compound Library
A14239
Cayman Chemical Bioactives
20249
26289
31609
ChEMBL Approved Drugs
CHEMBL1200323
CHEMBL429
ChEMBL Drugs
CHEMBL1200323
CHEMBL429
Concise Guide to Pharmacology 2017/18
7207
Concise Guide to Pharmacology 2019/20
7207
Concise Guide to Pharmacology 2021/22
7207
Concise Guide to Pharmacology 2023/24
7207
DrugBank
DB00598
DrugBank Approved Drugs
DB00598
DrugCentral
1531
DrugCentral Approved Drugs
1531
DrugMAP
DMK8U72
DrugMAP Approved Drugs
DMK8U72
DrugMatrix
Enamine Bioactive Compounds
EBC-80148
Guide to Pharmacology
7207
Ki Database
LABETALOL
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200323
CHEMBL429
MedChem Express Bioactive Compound Library
HY-B1108
HY-121383
NCATS Inxight Approved Drugs
R5H8897N95
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
labetalol-hcl
TargetMol Bioactive Compound Library
T0348
The Spectrum Collection
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
328.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
2.14
TPSA
95.58
Fraction CSP3
0.32
Chiral centers
2.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Adrenergic Receptor
α1-adrenergic receptor
Selectivity
beta
Member status
member
MOA
alpha-Adrenoceptor Antagonists
beta-Adrenoceptor Antagonists
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antihypertensive Agents
Source data