General
Preferred name
CISAPRIDE
Synonyms
(¡À)-Cisaprid ()
(??)-Cisaprid ()
R 51619 ()
Kaudalit ()
Kinestase ()
Prepulsid ()
Pridesia ()
(±)-Cisaprid ()
(R,S)-CISAPRIDE MONOHYDRATE ()
Cisapride ()
Cisapride-d6 ()
P&D ID
PD009896
CAS
81098-60-4
104860-66-4
Tags
natural product
drug
available
Drug Status
investigational
approved
withdrawn
Drug indication
Gastrointestinal disease
Gastroesophageal reflux disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist; upon activation of the receptor signaling pathway, cisapride promotes the release of acetylcholine neurotransmitters in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
DESCRIPTION
5-HT4 agonist; stimulates intestinal ACh release
(Tocriscreen Plus)
DESCRIPTION
5-HT4 agonist; stimulates intestinal ACh release
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
465.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
3.36
TPSA
86.05
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuroscience
Angiogenesis
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Neuronal Signaling
Target
5-HT
Potassium Channel
hERG channel
HTR2A, HTR3A, HTR4, KCNH2
5-HT Receptor
MOA
5-HT Receptor antagonist
Potassium Channel inhibitor
alpha-Adrenoceptor Antagonists
serotonin receptor agonist
Member status
virtual
Therapeutic Class
Gastrointestinal Agents
Source data
