General
Preferred name
BISOPROLOL
Synonyms
BISOPROLOL FUMARATE ()
Bisoprolol hemifumarate salt ()
(±)-Bisoprolol hemifumarate ()
(¡À)-Bisoprolol (hemifumarate) ()
(¡À)-Bisoprolol hemifumarate ()
Bisoprolol hemifumarate ()
(¡À)-Bisoprolol (hemifumarate)Bisoprolol hemifumarate salt ()
Bisoprolol (hemifumarate) ()
EMD33512 ()
Bisoprolol fumarate component of ziac ()
CL 297,939 ()
Bipranix ()
Vivacor ()
Isoten Mitis ()
Detensiel ()
Emcor ()
Concor ()
EMD-33-512 ()
Congescor ()
Emconcor ()
Isoten ()
EMD-33512 ()
CL-297939 ()
Euradal ()
Emcor LS ()
Speridol ()
Soprol ()
Monocor ()
Zebeta ()
Soloc ()
Cardicor ()
EMD 33 512 ()
Bisoprolol-d7 (hemifumarate) ()
P&D ID
PD009891
CAS
66722-44-9
104344-23-2
Tags
available
drug
Approved by
PMDA
FDA
First approval
1992
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
DESCRIPTION
Bisoprolol is a β-blocker, selective for β1-adrenoceptors in cardiac tissue. The S(-) enantiomer is believed to account for most of its β-blocking activity.
Marketed formulations may contain bisoprolol fumarate (PubChem CID 6917733). (GtoPdb)
Marketed formulations may contain bisoprolol fumarate (PubChem CID 6917733). (GtoPdb)
DESCRIPTION
Bisoprolol is a potent, selective and orally active ¦Â1-adrenergic receptor blocker with little activity on ¦Â2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].
DESCRIPTION
Bisoprolol hemifumarate is a potent, selective and orally active ¦Â1-adrenergic receptor blocker with little activity on ¦Â2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].
DESCRIPTION
Cardioselective Beta1-adrenoceptor antagonist. Actual molecular weight is 383.48
(LOPAC library)
DESCRIPTION
β1 antagonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
25
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
94
Molecular Weight
325.23
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
1
Aromatic Ring Count
1
cLogP
2.37
TPSA
59.95
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta1
Pathway
Neuronal Signaling
GPCR/G protein
MOA
Adrenergic Receptor inhibitor
Target
¦Â1-adrenergic receptor
Adrenergic Receptor
Therapeutic Class
Antihypertensive Agents
Source data
