General
Preferred name
BISOPROLOL
Synonyms
BISOPROLOL FUMARATE ()
Bisoprolol hemifumarate salt ()
(±)-Bisoprolol hemifumarate ()
(¡À)-Bisoprolol (hemifumarate) ()
(??)-Bisoprolol (hemifumarate) ()
EMD33512 ()
(??)-Bisoprolol hemifumarate ()
(¡À)-Bisoprolol hemifumarate ()
Bisoprolol hemifumarate ()
(¡À)-Bisoprolol (hemifumarate)Bisoprolol hemifumarate salt ()
Bisoprolol (hemifumarate) ()
CL-297939 ()
Zebeta ()
Emconcor ()
Soprol ()
Detensiel ()
Speridol ()
Vivacor ()
Emcor ()
Isoten Mitis ()
Euradal ()
Isoten ()
Monocor ()
Emcor LS ()
EMD-33512 ()
Bipranix ()
CL 297,939 ()
Congescor ()
Soloc ()
EMD-33-512 ()
Concor ()
Cardicor ()
Ziac ()
EMD 33 512 ()
Bisoprolol-d7 (hemifumarate) ()
P&D ID
PD009891
CAS
66722-44-9
104344-23-2
Tags
natural product
drug
available
Approved by
PMDA
FDA
First approval
1992
Drug Status
approved
Drug indication
Antihypertensive (beta-blocker)
Hypertension
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Bisoprolol is a β-blocker, selective for β1-adrenoceptors in cardiac tissue. The S(-) enantiomer is believed to account for most of its β-blocking activity.
Marketed formulations may contain bisoprolol fumarate (PubChem CID 6917733). (GtoPdb)
DESCRIPTION Cardioselective Beta1-adrenoceptor antagonist. Actual molecular weight is 383.48 (LOPAC library)
DESCRIPTION β1 antagonist (Tocriscreen Total)
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
A10149
Cayman Chemical Bioactives
23827
30760
ChEMBL Approved Drugs
CHEMBL1472989
CHEMBL645
ChEMBL Drugs
CHEMBL1472989
CHEMBL645
Concise Guide to Pharmacology 2023/24
7129
DrugBank
DB00612
DrugBank Approved Drugs
DB00612
DrugCentral
380
DrugCentral Approved Drugs
380
DrugMAP
DM3UZ95
DrugMAP Approved Drugs
DM3UZ95
DrugMatrix
Guide to Pharmacology
7129
Ki Database
Bisoprolol
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0076
NCATS Inxight Approved Drugs
Y41JS2NL6U
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Bisoprolol-Fumarate
bisoprolol
TargetMol Bioactive Compound Library
T0143
The Spectrum Collection
Tocriscreen Total
External IDs
90
Properties
(calculated by RDKit )
Molecular Weight
325.23
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
1
Aromatic Ring Count
1
cLogP
2.37
TPSA
59.95
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta1
Pathway
Neuronal Signaling
GPCR/G protein
Target
??1-adrenergic receptor
¦Â1-adrenergic receptor
Adrenergic Receptor
MOA
Adrenergic Receptor inhibitor
Therapeutic Class
Antihypertensive Agents
Source data