General
Preferred name
AMODIAQUINE
Synonyms
AMODIAQUINE HYDROCHLORIDE ()
Amodiaquin dihydrochloride dihydrate ()
Amodiaquine dihydrochloride dihydrate ()
Amodiaquine dihydrochloride dihydrate ()
Amodiaquine (dihydrochloride dihydrate) ()
Amodiaquine (dihydrochloride) ()
Amodiaquin (dihydrochloride dihydrate) ()
Amodiaquin (dihydrochloride) ()
Amodiaquin ()
Amodiaquine hydrochloride dihydrate ()
Amodiaquini hydrochloridum ()
NSC-755863 ()
Amodiaquine HCl ()
Camoquin hydrochloride ()
SJ000110703 ()
Sunoquine ()
Amodiaquinum ()
GNF-Pf-5648 ()
NSC-13453 ()
Amodiaquina ()
Amodiaquine-d10 ()
P&D ID
PD009890
CAS
6398-98-7
86-42-0
69-44-3
1021496-19-4
1189449-70-4
Tags
available
drug
Approved by
FDA
Drug indication
Malaria
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 ¦ÌM. Anti-inflammatory effect[1][2][3][4].
DESCRIPTION
Amodiaquine is the non-proprietary name of the active antimalarial that is contained in a number of drugs that are approved in jurisdictions in Africa (Kenya and Tanzania), Colombia and Pakistan. It is a 4-aminoquinoline compound related to .
Potential Target/Mechanism Of Action: As the precise mechanism of action of amodiaquine is not yet known, we do not have a molecular target for this compound.
Potential Target/Mechanism Of Action: As the precise mechanism of action of amodiaquine is not yet known, we do not have a molecular target for this compound.
DESCRIPTION
Amodiaquine is a 4-aminoquinoline antimalarial compound related to .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
PRICE
133
DESCRIPTION
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 ¦ÌM. Anti-inflammatory effect[1][2][3][4][5].
DESCRIPTION
Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent.
(Enamine Bioactive Compounds)
DESCRIPTION
Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Amodiaquine is a drug which used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It has similar action to chloroquine. It is not available in the United States, but widely available in Africa.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
9
Compound Sets
29
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
91
Molecular Weight
355.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
5.18
TPSA
48.39
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Histamine N-methyltransferase inhibitor
Histamine Methyltransferase Inhibitor
Antimalarial
Histamine Receptor agonist
Target
Ferriprotoporphyrin IX
Histone methyltransferase
Nurr1
Parasite
HNMT
Nuclear Hormone Receptor 4A/NR4A
Histone Methyltransferase,HNMT,Transferase
Immunology & Inflammation related
DNA/RNA Synthesis,Parasite
histamine N-methyl transferase
Pathway
Chromatin/Epigenetic
GPCR/G protein
Immunology/Inflammation
Microbiology/virology
Neuroscience
Anti-infection
Epigenetics
Vitamin D Related/Nuclear Receptor
Member status
member
Indication
malaria
ATC
P01BA06
Therapeutic Class
Antimalarials
Solubility
DMSO (Slightly), Methanol (Slightly)
Source data
