General
Preferred name
AMODIAQUINE
Synonyms
AMODIAQUINE HYDROCHLORIDE ()
Amodiaquin dihydrochloride dihydrate ()
Amodiaquine dihydrochloride dihydrate ()
Amodiaquine dihydrochloride dihydrate ()
Amodiaquine (dihydrochloride dihydrate) ()
Amodiaquine (dihydrochloride) ()
Amodiaquin (dihydrochloride dihydrate) ()
Amodiaquin ()
Amodiaquin (dihydrochloride) ()
Amodiaquini hydrochloridum ()
NSC-755863 ()
Camoquin ()
Camoquin hydrochloride ()
Amodiaquine HCl ()
Amodiaquinum ()
NSC-13453 ()
GNF-Pf-5648 ()
SJ000110703 ()
Sunoquine ()
TCMDC-123932 ()
Camoquin HCl ()
Amodiaquine-d10 ()
P&D ID
PD009890
CAS
6398-98-7
86-42-0
69-44-3
1021496-19-4
1189449-70-4
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
withdrawn
Drug indication
Antimalarial,Antiprotozoal
Antimalarial
Malaria
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Amodiaquine is the non-proprietary name of the active antimalarial that is contained in a number of drugs that are approved in jurisdictions in Africa (Kenya and Tanzania), Colombia and Pakistan. It is a 4-aminoquinoline compound related to .
Potential Target/Mechanism Of Action: As the precise mechanism of action of amodiaquine is not yet known, we do not have a molecular target for this compound.
Potential Target/Mechanism Of Action: As the precise mechanism of action of amodiaquine is not yet known, we do not have a molecular target for this compound.
DESCRIPTION
Amodiaquine is a 4-aminoquinoline antimalarial compound related to .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
Amodiaquine is a drug which used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It has similar action to chloroquine. It is not available in the United States, but widely available in Africa.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
11
Compound Sets
27
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
83
Molecular Weight
355.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
5.18
TPSA
48.39
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Histamine N-methyltransferase inhibitor
Histamine Methyltransferase Inhibitor
Antimalarial
Histamine Receptor agonist
Target
Ferriprotoporphyrin IX
histamine N-methyl transferase
HNMT
Histone methyltransferase
Parasite
Histone Methyltransferase,HNMT,Transferase
Immunology & Inflammation related
DNA/RNA Synthesis,Parasite
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Anti-infection
Epigenetics
Member status
member
Indication
malaria
ATC
P01BA06
Therapeutic Class
Antimalarials
Solubility
DMSO (Slightly), Methanol (Slightly)
Source data
