General
Preferred name
CANDOXATRIL
Synonyms
UK 79300 ()
UK-79300 ()
Candoxatrilo ()
UK-79,300 ()
P&D ID
PD009887
CAS
123122-55-4
Tags
available
prodrug
drug candidate
Drug Status
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
997
DESCRIPTION
This is the prodrug of candoxitrilat. This ligand is represented in PubChem by the entry CID 5362417.
(GtoPdb)
DESCRIPTION
Candoxatril (UK 79300) is an orally active neutral peptide endonuclease (NEP, EC 3.4.24.11) inhibitor that improves exercise capacity in patients with chronic heart failure undergoing angiotensin-converting enzyme inhibition.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
DrugBank
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
515.29
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
4
Aromatic Ring Count
1
cLogP
4.07
TPSA
111.16
Fraction CSP3
0.69
Chiral centers
1.0
Largest ring
6.0
QED
0.25
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
neutral endopeptidase (NEP)
Neprilysin
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
