General
Preferred name
DEMECLOCYCLINE
Synonyms
DEMECLOCYCLINE HYDROCHLORIDE ()
Demeclocycline HCl ()
Detravis ()
Clortetrin ()
Declomycin ()
Demeclocycline (hydrochloride) ()
Ledermycin ()
NSC-756708 ()
Demethylchlortetracycline hydrochloride ()
Declostatin ()
Demethylchlortetracycline ()
P&D ID
PD009886
CAS
127-33-3
64-73-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1960
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antibacterial
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Demeclocycline is a tetracycline antibiotic active against the following microorganisms: Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers), Mycoplasma pneumoniae (PPLO, Eaton agent), agents of psittacosis and ornithosis, agents of lymphogranulomavenereum and granuloma inguinale, the spirochetal agent of relapsing fever (Borrelia recurrentis), Haemophilus ducreyi (chancroid), Yersinia pestis, Pasteurella pestis and Pasteurella tularensis, Bartonella bacilliformis, Bacteroides species, Vibrio comma and Vibrio fetus, and Brucella species (in conjunction with streptomycin). Demeclocycline inhibits cell growth by inhibiting translation. Demeclocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Demeclocycline is not a direct bactericidal agent; rather, it is a bacteriostatic drug that impairs bacterial growth. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
DESCRIPTION Tetracycline antibiotic; interferes with protein synthesis (LOPAC library)
Cell lines
0
Organisms
3
Compound Sets
16
Cayman Chemical Bioactives
21759
ChEMBL Approved Drugs
CHEMBL1200474
CHEMBL1591
ChEMBL Drugs
CHEMBL1200474
CHEMBL1591
DrugBank
DB00618
DrugBank Approved Drugs
DB00618
DrugCentral
802
DrugCentral Approved Drugs
802
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200474
MedChem Express Bioactive Compound Library
HY-17560
HY-121268
NCATS Inxight Approved Drugs
5R5W9ICI6O
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
demeclocycline-hci
TargetMol Bioactive Compound Library
T1400
The Spectrum Collection
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
464.1
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
6
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
0.26
TPSA
181.62
Fraction CSP3
0.38
Chiral centers
5.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Protein synthesis
Pathway
Microbiology&virology
Anti-infection
Target
30S ribosome
antibiotic
Bacterial
Antibiotics,Bacterial
MOA
ribosome inhibitor
Source data