General
Preferred name
NICARDIPINE
Synonyms
NICARDIPINE HYDROCHLORIDE ()
RS-69216 ()
Nicardipine HCl ()
YC-93 Hydrochloride ()
Cardene ()
Dagan ()
Antagonil ()
Flusemide ()
Nicardipine (Hydrochloride) ()
YC-93 (free base) ()
YC-93 ()
RS-69216,YC-93 ()
Cardepine ()
Nerdipina ()
Nicardal ()
Rycarden ()
Dacarel ()
Lecibral ()
RS-69216-XX-07-0 ()
Cardene Sr ()
Vasonase ()
Nicant ()
Vasodin ()
Perdipine ()
Nicodel ()
Nimicor ()
Loxen ()
RS-69216XX07-0 ()
Barizin ()
Ridene ()
Rydene ()
Nicarpin ()
Lescodil ()
NSC-757855 ()
Lecibra ()
Perdipina ()
Nicapress ()
Ranvil ()
Nicardipine (stn) ()
Perpidine ()
Nicardipino ()
P&D ID
PD009884
CAS
54527-84-3
55985-32-5
69441-18-5
106664-28-2
Tags
available
drug
Approved by
FDA
First approval
1988
Drug indication
Hypertension
Cardiovascular disease
High blood pressure
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC50 of 1 ¦ÌM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure[1].
PRICE 29
DESCRIPTION One of the dihydropyridine class of drugs. (GtoPdb)
DESCRIPTION Nicardipine (YC-93 free base) is a calcium channel blocker with an IC50 of 1 ¦ÌM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure[1].
PRICE 29
DESCRIPTION L-type Ca2+ channel antagonist; antihypertensive (LOPAC library)
DESCRIPTION Nicardipine is a calcium channel blocker. (Enamine Bioactive Compounds)
DESCRIPTION Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator. (TargetMol Bioactive Compound Library)
DESCRIPTION Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
9
Compound Sets
27
Axon Medchem Screening Library
3254
Cayman Chemical Bioactives
17537
ChEMBL Approved Drugs
CHEMBL1200326
CHEMBL1484
ChEMBL Drugs
CHEMBL1200326
CHEMBL1484
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00622
DrugBank Approved Drugs
DB00622
DrugCentral
1909
DrugCentral Approved Drugs
1909
DrugMAP
DMCDYW7
DrugMAP Approved Drugs
DMCDYW7
DrugMatrix
Enamine Bioactive Compounds
EBC-12271
Enamine BioReference Compounds
Guide to Pharmacology
2559
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200326
CHEMBL1484
Mcule NIBR MoA Box Subset
MCULE-8941631263
MedChem Express Bioactive Compound Library
HY-12515A
HY-12515
NCATS Inxight Approved Drugs
CZ5312222S
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nicardipine-hcl
nicardipine
TargetMol Bioactive Compound Library
T1215
T21454
The Spectrum Collection
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
479.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
3.68
TPSA
111.01
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.33
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
L-type
Target
Calcium Channel
Ca channel antagonist
ADC Cytotoxin,Calcium Channel
Adrenergic Receptor
mAChR
Member status
member
MOA
Calcium Channel Blockers
Pathway
Autophagy
GPCR/G protein
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Neuronal Signaling
Therapeutic Class
Antihypertensive Agents
Source data