General
Preferred name
FLUPHENAZINE
Synonyms
FLUPHENAZINE HYDROCHLORIDE ()
FLUPHENAZINE DECANOATE ()
FLUPHENAZINE DIHYDROCHLORIDE ()
Prolixin ()
Permitil ()
Moditen ()
Fluphenazine (HCl) ()
Fluphenazine (dihydrochloride) ()
SQUIBB 4918 ()
Fluphenazine dihydrochloride ()
NSC-179197 ()
NSC-62323 ()
Fluphenazine ()
Fluphenazine HCl ()
Fluphenazine (hydrochloride) ()
P&D ID
PD009883
CAS
146-56-5
69-23-8
47646-09-3
Tags
nuisance
natural product
drug
available
Approved by
FDA
First approval
1959
Drug Status
approved
Drug indication
Severe acute respiratory syndrome (SARS)
Psychotic disorders
Psychotic disorder
Antipsychotic
Middle East Respiratory Syndrome (MERS)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fluphenazine belongs to the family of phenothiazine anti-psychotic drugs.
(GtoPdb)
DESCRIPTION
Dopamine receptor antagonist; antipsychotic
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
6
Compound Sets
25
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
437.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
4.31
TPSA
29.95
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1/D2
Pathway
GPCR/G protein
Neuroscience
Anti-infection
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
dopamine
CALM1, DRD1, DRD2, DRD5, HRH1, HTR2A, HTR6, HTR7
Dopamine Receptor
SARS-CoV
Sodium Channel
Indication
schizophrenia
MOA
Dopamine Receptor antagonist
Therapeutic Class
Antipsychotic Agents
Antiviral Agents
Source data
