General
Preferred name
BACITRACIN
Synonyms
Albac ()
Ziba-RX ()
BACITRACIN ZINC ()
bacitracin A ()
Baciim ()
Zutracin ()
Baci-Rx ()
Bacitracin(non-injectable) ()
Bacitracin component of lanabiotic ()
Bacilliquin ()
Fortracin ()
Baciferm 50 ()
Topitracin ()
Penitracin ()
Bacitracin component of mycitracin ()
Bacitracine ()
Albac 50 ()
Tropitracin ()
Parentracin ()
Bacitracina ()
Baciguent ()
Bacitracinum ()
E700 ()
Bacitracin, sterile ()
NSC-755905 ()
Bacitracins zinc complex ()
Noptracin ()
Bacitracin zinc component of polysporin ()
Bacifarmin ()
Bacitracins, zinc complex ()
Bacitracin zinc component of cortisporin ()
Bacitracin zinc component of neo-polycin ()
Bacitracin zinc component of ocumycin ()
Bacitracin zinc component of lanabiotic ()
Bacitracinum zincum ()
Zinc bacitracin ()
Bacitracin A (technical grade) ()
P&D ID
PD009882
CAS
1405-87-4
22601-59-8
Tags
available
drug
natural product
Drug indication
Inflammation
Pneumonia
Skin infection
Drug Status
vet_approved
approved
Max Phase
4.0
First approval
1957
1948
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. ; However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.
DESCRIPTION
Bacitracin A is a polypeptide antibacterial with activity against Gram-positive bacteria. It is the major component of bacitracin , a mixture of at least nine closely-related cyclic polypeptides produced by Bacillus licheniformis and Bacillus subtilis.
(GtoPdb)
DESCRIPTION
Bacitracin (Ziba-RX), a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
1421.75
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
17
Rotatable Bonds
31
Ring Count
4
Aromatic Ring Count
2
cLogP
-1.68
TPSA
530.87
Fraction CSP3
0.64
Chiral centers
15.0
Largest ring
25.0
QED
0.04
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
IDE
Indication
first-aid antibiotic
MOA
bacterial cell wall synthesis inhibitor
Pathway
Microbiology/virology
Therapeutic Class
Antibiotics
Source data
