General
Preferred name
dexmedetomidine
Synonyms
DEXMEDETOMIDINE HYDROCHLORIDE ()
(S)-Medetomidine hydrochloride ()
(+)-Medetomidine hydrochloride ()
Precedex ()
Dexmedetomidine HCl ()
(S)-Medetomidine hydrochloride(+)-Medetomidine hydrochloride ()
Dexmedetomidine (hydrochloride) ()
(+)-Medetomidine ()
(S)-Medetomidine ()
(+)-Medetomidine (hydrochloride) ()
(S)-Medetomidine (hydrochloride) ()
Sileo ()
Cepedex ()
Sedadex ()
Dexdomitor ()
Dexdor ()
Igalmi ()
MPV-1440 ()
Medetomidine, (s)- ()
Dexmedetomidine (hydrochloride) (CRM) ()
P&D ID
PD009878
CAS
145108-58-3
113775-47-6
Tags
natural product
drug
available
Approved by
PMDA
EMA
FDA
First approval
1999
Drug Status
approved
vet_approved
Drug indication
Tranquilizer
Irritability
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dexmedetomidine is a somewhat selective α2-adrenoceptor agonist with sedative properties. (GtoPdb)
DESCRIPTION Selective A2B antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 5160) (Tocriscreen Plus)
Compound Sets
27
AdooQ Bioactive Compound Library
A11846
Axon Medchem Screening Library
3065
Cayman Chemical Bioactives
15581
38806
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL2106195
CHEMBL778
ChEMBL Drugs
CHEMBL2106195
CHEMBL778
Concise Guide to Pharmacology 2017/18
521
Concise Guide to Pharmacology 2019/20
521
Concise Guide to Pharmacology 2021/22
521
Concise Guide to Pharmacology 2023/24
521
Drug Repurposing Hub
DrugBank
DB00633
DrugBank Approved Drugs
DB00633
DrugCentral
835
DrugCentral Approved Drugs
835
DrugMAP
DM93L4X
DrugMAP Approved Drugs
DM93L4X
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
521
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL778
MedChem Express Bioactive Compound Library
HY-17034A
HY-12719
NCATS Inxight Approved Drugs
67VB76HONO
Selleckchem Bioactive Compound Library
dexmedetomidine-hcl-precedex
TargetMol Bioactive Compound Library
T6466
T2524
Tocris Bioactive Compound Library
2749
Tocriscreen Plus
2749
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
200.13
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
3.18
TPSA
28.68
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
MOA
Adrenergic Receptor agonist
Agonist
Target
Adrenergic receptor alpha-2
??2-adrenoceptor
??2 receptor
ADRA2A, ADRA2B, ADRA2C
a2 agonist
Adrenergic Receptor
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Primary Target
Adrenergic ?2 Receptors
Indication
sedative
Therapeutic Class
Hypnotics and Sedatives
Source data