General
Preferred name
LEVOLEUCOVORIN
Synonyms
levofolinic acid ()
LEVOLEUCOVORIN CALCIUM ()
Levoleucovorin (Calcium) ()
Levofolene ()
Calcium Levofolinate ()
CL307782 ()
SODIUM LEVOFOLINATE ()
L-Folinic Acid (calcium salt hydrate) ()
Calcium levofolinate hydrate ()
CL 307,782 ()
CL-307782 ()
Calcium levofolinate pentahydrate ()
Levofolinate de calcium ()
Levofolinato de calcio ()
Elvorine ()
Calcium levofolinate (6s,l) ()
Folinic acid l-form calcium salt ()
Calcium (6s)-folinate ()
Fusilev ()
Isovorin ()
Levofolinate calcium ()
L-folinic acid ()
(6s)-leucovorin ()
Levofolinic acid ()
LFP-754 ()
Khapzory ()
(s)-leucovorin ()
P&D ID
PD009871
CAS
6035-45-6
80433-71-2
58-05-9
121451-09-0
68538-85-2
Tags
available
drug
drug candidate
Approved by
PMDA
FDA
First approval
2008
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
rectum cancer
colorectal adenocarcinoma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. (BOC Sciences Bioactive Compounds)
Compound Sets
13
AdooQ Bioactive Compound Library
A11626
BOC Sciences Bioactive Compounds
calcium-levofolinate-cas-80433-71-2-item-84-77701
Cayman Chemical Bioactives
23833
ChEMBL Approved Drugs
CHEMBL1908361
CHEMBL1908841
ChEMBL Drugs
CHEMBL1908361
CHEMBL1908841
CHEMBL3707343
Drug Repurposing Hub
DrugBank
DB11596
DrugBank Approved Drugs
DB11596
DrugCentral
4384
DrugCentral Approved Drugs
4384
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1908841
MedChem Express Bioactive Compound Library
HY-13667
HY-127009
NCATS Inxight Approved Drugs
990S25980Y
External IDs
97
Properties
(calculated by RDKit )
Molecular Weight
473.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
7
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.73
TPSA
219.84
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
osteosarcoma
MOA
folate receptor ligand
Target
Endogenous Metabolite
Antifolate
Pathway
Metabolic Enzyme/Protease
Cell Cycle/DNA Damage
Source data