General
Preferred name
pentazocine
Synonyms
Talwin ()
WIN-20228 ()
Fortral ()
(-)-pentazocine ()
(?)-Pentazocine ()
(?)-Pentazocine (CRM) ()
P&D ID
PD009870
CAS
359-83-1
68964-90-9
64024-15-3
Tags
available
drug
Drug indication
Pain
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (-)-pentazocine is one of the two enantiomers in the approved drug pentazocine. (-)-pentazocine is a κ-opioid receptor agonist, while (+)-pentazocine exhibits ten-fold greater affinity for the σ receptor. Pentazocine is a mixed agonist-antagonist opioid pain medication. It is postulated that pentazocine behaves as an agonist at the κ and σ opioid receptors and has weak antagonistic action at the μ receptor. (GtoPdb)
Compound Sets
7
Cayman Chemical Bioactives
36658
40226
DrugMAP
DM1XBHS
DrugMAP Approved Drugs
DM1XBHS
Guide to Pharmacology
1606
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL560
NCATS Inxight Approved Drugs
RP4A60D26L
Other bioactive compounds
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
285.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
3.88
TPSA
23.47
Fraction CSP3
0.58
Chiral centers
3.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Anesthetics
Source data