General
Preferred name
TRAZODONE
Synonyms
TRAZODONE HYDROCHLORIDE ()
AF-1161 ()
Trazodone HCl ()
KB-831 ()
Trazodone HCl ()
Trazodone (hydrochloride) ()
AF-1161 (free base) ()
AF-1161, KB-831 ()
Desyrel ()
NSC-292811 ()
Molipaxin CR ()
Molipaxin ()
Trialodine ()
Oleptro ()
J10.767K ()
Trittico ()
Trazodone (hydrochloride) (CRM) ()
Trazodone-d6 (hydrochloride) (CRM) ()
P&D ID
PD009868
CAS
25332-39-2
19794-93-5
19666-36-5
1181578-71-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1981
Drug Status
investigational
approved
Drug indication
Depression
Antidepressant
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain trazodone hydrochloride (PubChem CID 62935). (GtoPdb)
DESCRIPTION Potent ghrelin receptor inverse agonist (Tocris Bioactive Compound Library)
DESCRIPTION Atypical antidepressant (LOPAC library)
DESCRIPTION Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. It is a phenylpiperazine compound. Trazodone also has antianxiety (anxiolytic) and sleep-inducing (hypnotic) effects. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
30
AdooQ Bioactive Compound Library
A11703
BOC Sciences Bioactive Compounds
trazodone-hydrochloride-cas-25332-39-2-item-84-64218
Cayman Chemical Bioactives
19048
19049
19052
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1200798
CHEMBL621
ChEMBL Drugs
CHEMBL1200798
CHEMBL621
Drug Repurposing Hub
DrugBank
DB00656
DrugBank Approved Drugs
DB00656
DrugCentral
2717
DrugCentral Approved Drugs
2717
DrugMAP
DMK1GBJ
DrugMAP Approved Drugs
DMK1GBJ
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
213
JUMP-Target 1 Compound Set
5533
Ki Database
TRAZODONE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL621
MedChem Express Bioactive Compound Library
HY-B0478
HY-B0478A
NCATS Inxight Approved Drugs
YBK48BXK30
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
trazodone-hydrochloride-desyrel
trazodone
TargetMol Bioactive Compound Library
T1619
The Spectrum Collection
Tocris Bioactive Compound Library
6336
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
371.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
2.36
TPSA
45.78
Fraction CSP3
0.37
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
MOA
serotonin transporter inhibitor
Antagonist
adrenergic receptor antagonist, serotonin receptor antagonist, serotonin reuptake inhibitor
Target
Serotonin Transporter
Serotonin 2c (5-HT2c) receptor
Serotonin 2a (5-HT2a) receptor
5-HT
Sert (Sodium-dependent)
Adrenergic Receptor
H1 receptor
ADRA1A, ADRA2A, HRH1, HTR1A, HTR2A, HTR2B, HTR2C, SLC6A4
HTR2C
5-HT Receptor
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Neuronal Signaling
Primary Target
5-HT2A Receptors
Indication
depression
Therapeutic Class
Antidepressants
Source data