General
Preferred name
TRAZODONE
Synonyms
TRAZODONE HYDROCHLORIDE ()
KB-831 ()
Trazodone HCl ()
AF-1161 ()
Trazodone HCl ()
Trazodone (hydrochloride) ()
AF-1161 (free base) ()
AF-1161, KB-831 ()
Azona ()
Trazodone (hydrochloride) (CRM) ()
Trazodone-d6 (hydrochloride) (CRM) ()
Molipaxin ()
Desyrel ()
Trialodine ()
Oleptro ()
NSC-292811 ()
Molipaxin CR ()
Trazodona ()
Trittico ()
J10.767K ()
P&D ID
PD009868
CAS
25332-39-2
19794-93-5
19666-36-5
1181578-71-1
Tags
available
drug
Approved by
FDA
First approval
1981
Drug indication
Major depressive disorder
Depression
Obstructive sleep apnea
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Trazodone hydrochloride (AF-1161) is a serotonin receptor antagonist and reuptake inhibitor with anti-neuroinflammatory effects. Trazodone hydrochloride can be used for research in major depressive disorder and also holds potential for studies related to sleep disorders[1][2][3][4].
PRICE
29
DESCRIPTION
Trazodone (AF-1161 free base) is a serotonin receptor antagonist and reuptake inhibitor. Trazodone can be used for the research of major depressive disorder. Trazodone also has potential for sleep disorder research[1].
DESCRIPTION
Potent ghrelin receptor inverse agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Atypical antidepressant
(LOPAC library)
DESCRIPTION
Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. It is a phenylpiperazine compound. Trazodone also has antianxiety (anxiolytic) and sleep-inducing (hypnotic) effects.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. It inhibits 5-HT receptors: 5-HT 2A, 1A and 2C.
(Enamine Bioactive Compounds)
DESCRIPTION
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
32
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
JUMP-Target 1 Compound Set
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
71
Molecular Weight
371.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
2.36
TPSA
45.78
Fraction CSP3
0.37
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
MOA
serotonin transporter inhibitor
Antagonist
adrenergic receptor antagonist, serotonin receptor antagonist, serotonin reuptake inhibitor
Target
Serotonin Transporter
Serotonin 2c (5-HT2c) receptor
Serotonin 2a (5-HT2a) receptor
serotonin reuptake
ADRA1A, ADRA2A, HRH1, HTR1A, HTR2A, HTR2B, HTR2C, SLC6A4
HTR2C
5-HT Receptor
Adrenergic Receptor
Histamine Receptor
5-HT
H1 receptor
Sert (Sodium-dependent)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Primary Target
5-HT2A Receptors
Indication
depression
Therapeutic Class
Antidepressants
Source data
