General
Preferred name
TRIMETHOBENZAMIDE
Synonyms
TRIMETHOBENZAMIDE HYDROCHLORIDE ()
Trimethobenzamide D6 ()
Ro 2-9578 ()
Tribenzagan Hydrochloride ()
Trimethobenzamide (hydrochloride) ()
NSC-37882 ()
Trimethobenzamide HCl ()
Trimethobenzamide hydrochloride preservative free ()
Tigan ()
Ametik damla ()
P&D ID
PD009863
CAS
554-92-7
138-56-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1974
Drug Status
investigational
approved
Max Phase
Phase 4
Drug indication
Anti-Emetic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations contain trimethobenzamide hydrochloride. (GtoPdb)
DESCRIPTION Trimethobenzamide hydrochloride is the hydrochloride salt form of trimethobenzamide, which is a benzamide derivative with antiemetic property. It is an orally available, antiemetic agent used in the therapy of nausea and vomiting and gastrointestinal, viral and other illnesses. It is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems. It inhibits the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center, thereby suppressing nausea and vomiting. It is also used in the treatment of Parkinson's disease. It has been withdrawn from the market. (BOC Sciences Bioactive Compounds)
Compound Sets
22
BOC Sciences Bioactive Compounds
trimethobenzamide-hydrochloride-cas-554-92-7-item-124935
Cayman Chemical Bioactives
24145
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1200887
CHEMBL1201256
ChEMBL Drugs
CHEMBL1200887
CHEMBL1201256
Drug Repurposing Hub
DrugBank
DB00662
DrugBank Approved Drugs
DB00662
DrugCentral
2754
DrugCentral Approved Drugs
2754
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7614
MedChem Express Bioactive Compound Library
HY-12751A
NCATS Inxight Approved Drugs
WDQ5P1SX7Q
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
trimethobenzamide-hydrochloride
TargetMol Bioactive Compound Library
T5009
The Spectrum Collection
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
388.2
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
2
cLogP
2.58
TPSA
69.26
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.67
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
Dopamine Receptor
Histamine Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Anti-infection
Neuronal Signaling
Target
D2
DRD2
Influenza Virus
Indication
vomiting, nausea, gastroenteritis
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Source data