General
Preferred name
ISOFLUROPHATE
Synonyms
Fluorostigmine ()
DIISOPROPYL FLUOROPHOSPHATE ()
DFP ()
fluostigmine ()
diisopropyl fluoridophosphate ()
NSC-727370 ()
Dyflos ()
Floropryl ()
P&D ID
PD009854
CAS
55-91-4
37209-35-1
Tags
covalent binder
drug
available
Approved by
FDA
First approval
1957
Drug Status
investigational
approved
withdrawn
Drug indication
Glaucoma/ocular hypertension
Cholinergic (ophthalmic)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Compound Sets
17
ChEMBL Approved Drugs
CHEMBL1025
ChEMBL Drugs
CHEMBL1025
CovBinderInPDB
CBR000255
CBR001183
CBR001184
CBR001428
CBR001429
CBR001822
CBR002244
CBR002245
CBR002247
CBR002554
CBR002640
CBR002936
CBR002937
CBR003128
CBR003129
CBR003369
CBR004327
CBR004328
CBR004633
CBR004690
CBR005075
CBR005076
CBR005077
CBR005078
CBR005079
CBR005080
CBR005081
CBR005090
CBR005091
CBR005255
CBR005775
CBR005776
CBR006470
CBR006471
CBR006472
CBR007370
CBR007371
CBR007481
CBR007482
Drug Repurposing Hub
DrugBank
DB00677
DrugBank Approved Drugs
DB00677
DrugCentral
1494
DrugCentral Approved Drugs
1494
DrugMAP
DMBSK7X
DrugMAP Approved Drugs
DMBSK7X
DrugMatrix
Ki Database
DFP
Diisopropyl fluorophosphate
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1025
NPC Screening Collection
ReFrame library
Withdrawn 2.0
DB00677
ZINC Tool Compounds
ZINC000008214587
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
184.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
2.91
TPSA
35.53
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACHE, BCHE
Indication
glaucoma
MOA
cholinesterase inhibitor
ATC
S01EB07
Therapeutic Class
Antiglaucomic Agents
Source data