General
Preferred name
THIORIDAZINE
Synonyms
THIORIDAZINE HYDROCHLORIDE ()
Hydrochloride, thioridazin ()
Mellaril ()
Aldazine ()
Thioridazine (HCl) ()
Thioridazine HCl ()
Thioridazine (hydrochloride) ()
Aldazine, Mellaril ()
Sonapax ()
Thioridazine Hydrochloride Intensol ()
NSC-186060 ()
Dl-thioridazine ()
Mellerette ()
Melleril ()
TP-21 ()
Thioridazine prolongatum ()
Tioridazina ()
Thioril ()
Rideril ()
Mellaril-s ()
Novoridazine ()
Thioridazine-d3 (hydrochloride) ()
P&D ID
PD009853
CAS
130-61-0
107388-89-6
50-52-2
1189928-36-6
Tags
available
drug
nuisance
obsolete probe
Approved by
FDA
First approval
1962
Drug indication
Schizophrenia
Psychosis
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
DESCRIPTION
Marketed formulations may contain thioridazine hydrochloride (PubChem CID 66062).
(GtoPdb)
DESCRIPTION
Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
DESCRIPTION
H1 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Dopamine receptor antagonist; Ca2+ channel antagonist; antipsychotic
(LOPAC library)
DESCRIPTION
Thioridazine hydrochloride is a dopamine receptor antagonist displaying antipsychotic activity. Thioridazine induces apoptosis via targeting the PI 3-K/Akt/mTOR/p70 S6K pathway, and induces G1 cell cycle arrest. Thioridazine exhibits anticancer activity in cervical, endometrial and breast cancer cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Thioridazine hydrochloride binds to dopamine D2, histamine H1, M3 muscarinic, and alpha1-adrenergic receptor. Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis.
(Enamine Bioactive Compounds)
DESCRIPTION
Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Thioridazine is an inhibitor of CYP1A2 and CYP3A2. It is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. It was developed by Novartis and has been listed, but it was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias, however, generic versions are available in the US.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
4
Compound Sets
37
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Obsolete Compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
VGSC-DB
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
370.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
5.89
TPSA
6.48
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1/D2
Primary Target
Non-selective Dopamine
MOA
Antagonist
Dopamine D2 Antagonists
Dopamine Receptor antagonist
Member status
virtual
Target
DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR1A, HTR2A, HTR2C, HTR6, HTR7
MALT1 inhibitor
DA antag.
5-HT Receptor
Bacterial
Dopamine Receptor
5-HT
Adrenergic Receptor
dopamine
Potassium Channel
ATC
N05AC02
Toxicity type
cardiovascular
Pathway
Apoptosis
Autophagy
GPCR/G protein
Membrane Transporter/Ion Channel
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Therapeutic Class
Antipsychotic Agents
VGSC Target
Nav1.5
Solubility
Soluble in DMSO, not in water
Source data
