General
Preferred name
THIORIDAZINE
Synonyms
THIORIDAZINE HYDROCHLORIDE ()
Hydrochloride, thioridazin ()
Aldazine ()
Mellaril ()
Thioridazine (HCl) ()
Thioridazine HCl ()
Thioridazine (hydrochloride) ()
Aldazine, Mellaril ()
Thioridazine Hydrochloride Intensol ()
NSC-186060 ()
Sonapax ()
Dl-thioridazine ()
Mellerette ()
Thioril ()
Rideril ()
Thioridazine prolongatum ()
TP-21 ()
Mellaril-s ()
Novoridazine ()
Melleril ()
Thioridazine-d3 (hydrochloride) ()
P&D ID
PD009853
CAS
130-61-0
107388-89-6
50-52-2
1189928-36-6
Tags
obsolete probe
nuisance
natural product
drug
available
Approved by
FDA
First approval
1962
Drug Status
approved
withdrawn
Drug indication
Antipsychotic
Sedative-Hypnotic,Sedative-Hypnotic
Schizophrenia
Sedative-Hypnotic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain thioridazine hydrochloride (PubChem CID 66062). (GtoPdb)
DESCRIPTION H1 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Dopamine receptor antagonist; Ca2+ channel antagonist; antipsychotic (LOPAC library)
DESCRIPTION Thioridazine hydrochloride is a dopamine receptor antagonist displaying antipsychotic activity. Thioridazine induces apoptosis via targeting the PI 3-K/Akt/mTOR/p70 S6K pathway, and induces G1 cell cycle arrest. Thioridazine exhibits anticancer activity in cervical, endometrial and breast cancer cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION Thioridazine is an inhibitor of CYP1A2 and CYP3A2. It is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. It was developed by Novartis and has been listed, but it was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias, however, generic versions are available in the US. (BOC Sciences Bioactive Compounds)
Cell lines
9
Organisms
4
Compound Sets
35
AdooQ Bioactive Compound Library
A11119
Axon Medchem Screening Library
2193
BOC Sciences Bioactive Compounds
thioridazine-hydrochloride-cas-130-61-0-item-170388
thioridazine-cas-50-52-2-item-69873
Cayman Chemical Bioactives
14400
30239
ChEMBL Approved Drugs
CHEMBL1200916
CHEMBL479
ChEMBL Drugs
CHEMBL1200916
CHEMBL479
Drug Repurposing Hub
DrugBank
DB00679
DrugBank Approved Drugs
DB00679
DrugCentral
2637
DrugCentral Approved Drugs
2637
DrugMAP
DM35M8J
DrugMAP Approved Drugs
DM35M8J
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
100
Ki Database
THIORIDAZINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL479
Mcule NIBR MoA Box Subset
MCULE-7796139302
MedChem Express Bioactive Compound Library
HY-B0965
NCATS Inxight Approved Drugs
4WCI67NK8M
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Obsolete Compounds
thioridazine
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
thioridazine-hydrochloride
TargetMol Bioactive Compound Library
T0365
The Spectrum Collection
Tocris Bioactive Compound Library
3070
VGSC-DB
NA0076
Withdrawn 2.0
w78
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
370.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
5.89
TPSA
6.48
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1/D2
Pathway
Neuroscience
GPCR/G protein
Membrane Transporter/Ion Channel
Anti-infection
Apoptosis
Autophagy
Neuronal Signaling
Target
5-HT
Adrenergic Receptor
dopamine
Potassium Channel
DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR1A, HTR2A, HTR2C, HTR6, HTR7
MALT1 inhibitor
DA antag.
5-HT Receptor
Bacterial
Dopamine Receptor
Primary Target
Non-selective Dopamine
MOA
Antagonist
Dopamine D2 Antagonists
Dopamine Receptor antagonist
Member status
virtual
ATC
N05AC02
Toxicity type
cardiovascular
Therapeutic Class
Antipsychotic Agents
VGSC Target
Nav1.5
Solubility
Soluble in DMSO, not in water
Source data