General
Preferred name
MORICIZINE
Synonyms
moracizine ()
MORICIZINE HYDROCHLORIDE ()
Moricizine (Hydrochloride) ()
EN 313 ()
Ethmozin ()
Moricizine hcl ()
Moracizine hydrochloride ()
Ethmozine ()
EN-313 FREE BASE ()
Moracizina ()
EN-313 ()
P&D ID
PD009852
CAS
29560-58-5
31883-05-3
Tags
available
drug
Approved by
FDA
First approval
1990
Drug indication
Heart arrhythmia
cardiac arrhythmia
Arrhythmia
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1].
DESCRIPTION Moracizine is a phenothiazine derivative class Ic antiarrhythmic drug. Marketing by the original manufacturer has been discontinued. (GtoPdb)
Compound Sets
16
ChEMBL Approved Drugs
CHEMBL1200334
CHEMBL1075
ChEMBL Drugs
CHEMBL1200334
CHEMBL1075
Drug Repurposing Hub
DrugBank
DB00680
DrugBank Approved Drugs
DB00680
DrugCentral
1842
DrugCentral Approved Drugs
1842
DrugMAP
DMOMBJW
DrugMAP Approved Drugs
DMOMBJW
DrugMatrix
Guide to Pharmacology
7244
MedChem Express Bioactive Compound Library
HY-B0615A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
DB00680
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
427.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
4.11
TPSA
71.11
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Sodium Channel
SCN5A
Cytochrome P450
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Indication
ventricular arrhythmias
MOA
Sodium Channel blocker
ATC
C01BG01
Therapeutic Class
Antiarrhythmic Agents
Source data