General
Preferred name
AMPHOTERICIN B
Synonyms
Amphotericin ()
NSC 527017 ()
Ambisome ()
Fungilin In Orabase ()
Amphotec ()
Amphotericin b liposomal complex ()
Amphotericinum b ()
Fungilin ()
NSC-527017 ()
Amphotericin b liposome ()
Ampho-Moronal ()
Amphotericin b lipid complex ()
Abelcet ()
Amphotericin b, liposome ()
Amphotercin B ()
Amophotericin B ()
Ampotericin B ()
Ambil ()
Amphotericin b deoxycholate ()
Fungizone ()
Amphotericin b liposomal ()
Amfotericina b ()
Abelcet, liposomal amphotericin b ()
Amphotocerin ()
Halizon ()
Amphotericine B ()
Amphotericitin B ()
Amphotreicin B ()
P&D ID
PD009851
CAS
1397-89-3
Tags
available
drug
Approved by
FDA
First approval
1964
Drug indication
Fungal infection
Leishmaniasis
Mycoses
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
Cell lines
14
Organisms
33
Compound Sets
17
AdooQ Bioactive Compound Library
A10073
Cayman Chemical Bioactives
11636
ChEMBL Approved Drugs
CHEMBL267345
ChEMBL Drugs
CHEMBL267345
Drug Repurposing Hub
DrugBank
DB00681
DrugBank Approved Drugs
DB00681
DrugCentral
197
DrugCentral Approved Drugs
197
DrugMAP
DMTAJQE
DrugMAP Approved Drugs
DMTAJQE
MedChem Express Bioactive Compound Library
HY-B0221
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Amphotericin-B(Abelcet)
The Pathogen Box
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
923.49
Hydrogen Bond Acceptors
17
Hydrogen Bond Donors
12
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
0
cLogP
0.71
TPSA
319.61
Fraction CSP3
0.66
Chiral centers
19.0
Largest ring
36.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
MOA
Antibiotic
membrane permeability enhancer
Pathway
Microbiology&virology
Anti-infection
Indication
fungal infection
Target
antibiotic
Bacterial
Fungal
Parasite
Antibiotics,Antibiotics for Mammalian Cell Culture
Therapeutic Class
Antifungal Agents
Source data