General
Preferred name
FLUDROCORTISONE
Synonyms
9¦Á-Fludrocortisone ()
9¦Á-Fluorcortisol ()
9??-Fludrocortisone ()
9??-Fluorcortisol ()
9α-Fludrocortisone ()
9α-Fluorcortisol ()
Astonin-h ()
Alflorone ()
NSC-11318 ()
Fludrocortisone ()
P&D ID
PD009847
CAS
127-31-1
Tags
available
drug
Drug indication
Cerebral salt-wasting syndrome
Drug Status
investigational
approved
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fludrocortisone is a synthetic mineralocorticoid drug. Although fludrocortisone has some glucocorticoid receptor (GR) agonist activity, it is considered as MR 'selective' in its extensive clinical use for mineralocorticoid replacement.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
NURSA ligand set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
380.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.87
TPSA
94.83
Fraction CSP3
0.81
Chiral centers
7.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antiinflammatory Agents
Pathway
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Mineralocorticoid Receptor
Source data
